Design, synthesis and biological evaluation of novel tumor hypoxia-activated EGFR tyrosine kinase inhibitors.

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第一作者： Tingting,Jia

第一单位： School of Medicine, Zhejiang University City College, Hangzhou 310015, China; Department of Pharmacy, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, 310052, China.

作者： Tingting,Jia ^[1] ; Ruoyang,Miao ^[2] ; Jiaohua,Lin ^[3] ; Chong,Zhang ^[4] ; Linghui,Zeng ^[4] ; Jiankang,Zhang ^[4] ; Jiaan,Shao ^[4] ; Zongfu,Pan ^[5] ; Haiping,Wang ^[6] ; Huajian,Zhu ^[7] ; Weiyan,Cheng ^[8]

作者单位： School of Medicine, Zhejiang University City College, Hangzhou 310015, China; Department of Pharmacy, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, 310052, China. ^[1] Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China. ^[2] Zhejiang Yongtai Technology Co. Ltd, Taizhou 317016, China. ^[3] School of Medicine, Zhejiang University City College, Hangzhou 310015, China. ^[4] Center for Clinical Pharmacy, Cancer Center, Department of Pharmacy, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou 310014, China. ^[5] Hangzhou Children's Hospital, Hangzhou, 310014, China. Electronic address: 394219886@qq.com. ^[6] School of Medicine, Zhejiang University City College, Hangzhou 310015, China. Electronic address: zhuhj@zucc.edu.cn. ^[7] Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China. Electronic address: fccchengwy@zzu.edu.cn. ^[8]

关键词 AZD9291 EGFR inhibitors Hypoxia-activated L858R/T790M and del19 mutants Selective

主题词人类(Humans);蛋白激酶抑制剂(Protein Kinase Inhibitors);肺肿瘤(Lung Neoplasms);细胞系, 肿瘤(Cell Line, Tumor);细胞增殖(Cell Proliferation);突变(Mutation);抗肿瘤药(Antineoplastic Agents)

DOI 10.1016/j.bioorg.2022.106138

PMID 36115310

发布时间 2022-12-22

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