De novo annotation of lncRNA HOTAIR transcripts by long-read RNA capture-seq reveals a differentiation-driven isoform switch.

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作者： Evdokiia,Potolitsyna ^[1] ; Sarah,Hazell Pickering ^[1] ; Ave,Tooming-Klunderud ^[2] ; Philippe,Collas ^[3] ; Nolwenn,Briand ^[4]

作者单位： Department of Molecular Medicine, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, PO Box 1112, 0317, Oslo, Blindern, Norway. ^[1] Department of Immunology and Transfusion Medicine, Oslo University Hospital, 0424, Oslo, Norway. ^[2] Centre for Ecological and Evolutionary Synthesis, Department of Biosciences, University of Oslo, Oslo, Norway. ^[3] Department of Molecular Medicine, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, PO Box 1112, 0317, Oslo, Blindern, Norway. philc@medisin.uio.no. ^[4] Department of Immunology and Transfusion Medicine, Oslo University Hospital, 0424, Oslo, Norway. philc@medisin.uio.no. ^[5] Department of Molecular Medicine, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, PO Box 1112, 0317, Oslo, Blindern, Norway. nolwenn.briand@medisin.uio.no. ^[6] Department of Immunology and Transfusion Medicine, Oslo University Hospital, 0424, Oslo, Norway. nolwenn.briand@medisin.uio.no. ^[7]

关键词 Adipose differentiation Adipose stem cells Capture-seq HOTAIR Long-read sequencing lncRNA isoform

主题词细胞分化(Cell Differentiation);组蛋白脱甲基酶类(Histone Demethylases);人类(Humans);蛋白质亚型(Protein Isoforms)

DOI 10.1186/s12864-022-08887-w

PMID 36115964

发布时间 2022-10-11

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