Synthesis and anti-tumor activity of nitrogen-containing derivatives of the natural product diphyllin.

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第一作者： Yang,Li

第一单位： Targeted Drug Research Center of Digestive Tract Tumor, Pharm-X Center, School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, China.

作者： Yang,Li ^[1] ; Qing,Lu ^[1] ; Ruoxuan,Xiao ^[1] ; Jing,Ma ^[1] ; Yuqi,Tang ^[2] ; Wantao,Chen ^[3] ; Ruihan,Zhang ^[4] ; Lingxi,Jiang ^[5] ; Hao,Chen ^[5] ; Baiyong,Shen ^[5] ; Ao,Zhang ^[6] ; Chunyong,Ding ^[7]

作者单位： Targeted Drug Research Center of Digestive Tract Tumor, Pharm-X Center, School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, China. ^[1] Targeted Drug Research Center of Digestive Tract Tumor, Pharm-X Center, School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, China; Department of Oral and Maxillofacial-Head & Neck Oncology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, Shanghai, 200011, China. ^[2] Department of Oral and Maxillofacial-Head & Neck Oncology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, Shanghai, 200011, China. ^[3] WLSA Shanghai Academy, Shanghai, 200433, China. ^[4] Research Institute of Pancreatic Disease, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, 200025, Shanghai, China. ^[5] Targeted Drug Research Center of Digestive Tract Tumor, Pharm-X Center, School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, China. Electronic address: ao6919zhang@sjtu.edu.cn. ^[6] Targeted Drug Research Center of Digestive Tract Tumor, Pharm-X Center, School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, China. Electronic address: chunding@sjtu.edu.cn. ^[7]

关键词 Anticancer activity Diphyllin derivatives Druglike property Natural product Pancreatic cancer