首页> Cancer cell international> Intratumoral delivery of TransCon<sup>™</sup> TLR7/8 Agonist promotes sustained anti-tumor activity and local immune cell activation while minimizing systemic cytokine induction.

Intratumoral delivery of TransCon<sup>™</sup> TLR7/8 Agonist promotes sustained anti-tumor activity and local immune cell activation while minimizing systemic cytokine induction.

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第一作者： Luis Alejandro,Zúñiga

第一单位： Ascendis Pharma, Inc., Redwood City, CA, USA.

作者： Luis Alejandro,Zúñiga ^[1] ; Torben,Leßmann ^[2] ; Karan,Uppal ^[1] ; Nicola,Bisek ^[2] ; Enping,Hong ^[1] ; Caroline E,Rasmussen ^[3] ; Jens-Jakob,Karlsson ^[3] ; Joachim,Zettler ^[2] ; Lars,Holten-Andersen ^[3] ; Kathy,Bang ^[1] ; Dhruv,Thakar ^[1] ; Yu-Chi,Lee ^[1] ; Salomon,Martinez ^[1] ; Simran Singh,Sabharwal ^[1] ; Sebastian,Stark ^[2] ; Frank,Faltinger ^[2] ; Oliver,Kracker ^[2] ; Samuel,Weisbrod ^[2] ; Robin,Müller ^[2] ; Tobias,Voigt ^[2] ; Kornelia,Bigott ^[2] ; Mohammad,Tabrizifard ^[1] ; Vibeke Miller,Breinholt ^[3] ; Amer M,Mirza ^[1] ; David B,Rosen ^[1] ; Kennett,Sprogøe ^[4] ; Juha,Punnonen ^[1]

作者单位： Ascendis Pharma, Inc., Redwood City, CA, USA. ^[1] Ascendis Pharma GmbH, Heidelberg, Germany. ^[2] Ascendis Pharma A/S, Hellerup, Copenhagen, Denmark. ^[3] Ascendis Pharma A/S, Hellerup, Copenhagen, Denmark. ks@ascendispharma.com. ^[4]

关键词 Adaptive immunity Innate immunity Intratumoral injection Intratumoral treatment Toll-like receptor Tumor microenvironment

DOI 10.1186/s12935-022-02708-6

PMID 36123697

发布时间 2022-09-24

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