Age-dependent increased sag amplitude in human pyramidal neurons dampens baseline cortical activity.

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作者： Alexandre,Guet-McCreight ^[1] ; Homeira Moradi,Chameh ^[2] ; Sara,Mahallati ^[2] ; Margaret,Wishart ^[3] ; Shreejoy J,Tripathy ^[1] ; Taufik A,Valiante ^[1] ; Etay,Hay ^[4]

作者单位： Krembil Centre for Neuroinformatics, Centre for Addiction and Mental Health, 250 College St, Toronto, ON M5T 1R8, Canada. ^[1] Krembil Brain Institute, University Health Network, Toronto, ON M5T1M8, Canada. ^[2] Institute of Biomedical Engineering, University of Toronto, Toronto, ON M5S 3G9, Canada. ^[3] Department of Psychiatry, University of Toronto, Toronto, Ontario M5T 1R8, Canada. ^[4] Institute of Medical Sciences, University of Toronto, Toronto, ON M5S 1A8, Canada. ^[5] Department of Physiology, University of Toronto, Toronto, ON M5S1A8, Canada. ^[6] Department of Electrical and Computer Engineering, University of Toronto, Toronto, ON M5S 3G4, Canada. ^[7] Department of Surgery, University of Toronto, Toronto, ON M5T 1P5, Canada. ^[8] Center for Advancing Neurotechnological Innovation to Application, University of Toronto, Toronto, ON M5G 2A2, Canada. ^[9] Max Planck-University of Toronto Center for Neural Science and Technology, Toronto, ON, Canada. ^[10]

关键词 biophysical models computational neuroscience cortical microcircuits human aging network spiking

主题词老年人(Aged);人类(Humans);动作电位(Action Potentials);脑(Brain);神经元(Neurons);锥体细胞(Pyramidal Cells)

DOI 10.1093/cercor/bhac348

PMID 36124673

发布时间 2023-04-28

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准确一般字义偏差语意偏离译文作用小提交