NLRC5 restricts dengue virus infection by promoting the autophagic degradation of viral NS3 through E3 ligase CUL2 (cullin 2).

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第一作者： Jiawei,Hao

第一单位： Institute of Human Virology, Department of Pathogen Biology and Biosecurity, and Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, China.

作者： Jiawei,Hao ^[1] ; Jinqian,Li ^[2] ; Zhenzhen,Zhang ^[1] ; Yang,Yang ^[1] ; Qing,Zhou ^[1] ; Tiantian,Wu ^[1] ; Tongling,Chen ^[1] ; Zhongdao,Wu ^[3] ; Ping,Zhang ^[4] ; Jun,Cui ^[5] ; Yi-Ping,Li ^[6]

作者单位： Institute of Human Virology, Department of Pathogen Biology and Biosecurity, and Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, China. ^[1] Institute of Human Virology, Department of Pathogen Biology and Biosecurity, and Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, China.;Key Laboratory of Tropical Translational Medicine of Ministry of Education, NHC Key Laboratory of Control of Tropical Diseases, School of Tropical Medicine, Hainan Medical University, Haikou, Hainan, China. ^[2] Parasitology Unit, Department of Pathogen Biology and Biosecurity, and Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, China. ^[3] Department of Microbiology and Immunology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, China. ^[4] MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong, China. ^[5] Institute of Human Virology, Department of Pathogen Biology and Biosecurity, and Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, China.;Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China. ^[6]

关键词 Antiviral immunity TOLLIP flavivirus selective autophagy ubiquitination