Small soluble α-synuclein aggregates are the toxic species in Parkinson's disease.

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第一作者： Derya,Emin

第一单位： Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK.

作者： Derya,Emin ^[1] ; Yu P,Zhang ^[2] ; Evgeniia,Lobanova ^[1] ; Alyssa,Miller ^[2] ; Xuecong,Li ^[1] ; Zengjie,Xia ^[2] ; Helen,Dakin ^[1] ; Dimitrios I,Sideris ^[3] ; Jeff Y L,Lam ^[4] ; Rohan T,Ranasinghe ^[1] ; Antonina,Kouli ^[2] ; Yanyan,Zhao ^[1] ; Suman,De ^[2] ; Tuomas P J,Knowles ^[1] ; Michele,Vendruscolo ^[1] ; Francesco S,Ruggeri ^[2] ; Franklin I,Aigbirhio ^[1] ; Caroline H,Williams-Gray ^[5] ; David,Klenerman ^[6]

作者单位： Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK. ^[1] UK Dementia Research Institute, University of Cambridge, Cambridge, UK. ^[2] Laboratory of Organic Chemistry, Wageningen University and Research, Wageningen, Netherlands. ^[3] Physical Chemistry and Soft Matter, Wageningen University and Research, Wageningen, Netherlands. ^[4] John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK. ^[5] Molecular Imaging Chemistry Laboratory, Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK. ^[6] Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK. ^[7] Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK. dk10012@cam.ac.uk. ^[8] UK Dementia Research Institute, University of Cambridge, Cambridge, UK. dk10012@cam.ac.uk. ^[9]

主题词脑(Brain);人类(Humans);脂质体(Liposomes);帕金森病(Parkinson Disease);α突触核蛋白(alpha-Synuclein)

DOI 10.1038/s41467-022-33252-6

PMID 36127374

发布时间 2022-11-02

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