Optimization of N-Piperidinyl-Benzimidazolone Derivatives as Potent and Selective Inhibitors of 8-Oxo-Guanine DNA Glycosylase 1.

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作者： Olov,Wallner ^[1] ; Armando,Cázares-Körner ^[1] ; Emma Rose,Scaletti ^[2] ; Geoffrey,Masuyer ^[2] ; Tove,Bekkhus ^[1] ; Torkild,Visnes ^[1] ; Kirill,Mamonov ^[3] ; Florian,Ortis ^[1] ; Thomas,Lundbäck ^[1] ; Maria,Volkova ^[4] ; Tobias,Koolmeister ^[1] ; Elisée,Wiita ^[1] ; Olga,Loseva ^[1] ; Monica,Pandey ^[1] ; Evert,Homan ^[1] ; Carlos,Benítez-Buelga ^[1] ; Jonathan,Davies ^[1] ; Martin,Scobie ^[5] ; Ulrika,Warpman Berglund ^[2] ; Christina,Kalderén ^[1] ; Pål,Stenmark ^[6] ; Thomas,Helleday ^[1] ; Maurice,Michel ^[6]

作者单位： Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 77, Stockholm, Sweden. ^[1] Department of Biochemistry and Biophysics, Stockholm University, 10691, Stockholm, Sweden. ^[2] Department of Biotechnology and Nanomedicine, SINTEF Industry, 7465, Trondheim, Norway. ^[3] Chemical Biology Consortium Sweden (CBCS), Science for Life Laboratory, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 77, Stockholm, Sweden. ^[4] Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Madrid, Spain. ^[5] Oxcia AB, 113 34, Stockholm, Sweden. ^[6] Department of Experimental Medical Science, Lund University, 221 00, Lund, Sweden. ^[7] Sheffield Cancer Centre, Department of Oncology and Metabolism, University of Sheffield, S10 2TN, Sheffield, UK. ^[8]

关键词 8-oxo guanine DNA glycoslyase 1 Base excision repair Inhibitors OGG1 TH5487

主题词人类(Humans);DNA糖基化酶类(DNA Glycosylases);鸟嘌呤(Guanine);DNA修复(DNA Repair);苯咪唑类(Benzimidazoles);DNA损伤(DNA Damage);肿瘤(Neoplasms)

DOI 10.1002/cmdc.202200310

PMID 36128847

发布时间 2023-04-15

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