Specific transcriptional programs differentiate ICOS from CD28 costimulatory signaling in human Naïve CD4<sup>+</sup> T cells.

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作者： Casimiro Luca,Gigliotti ^[1] ; Elena,Boggio ^[2] ; Francesco,Favero ^[1] ; Danny,Incarnato ^[2] ; Claudio,Santoro ^[1] ; Salvatore,Oliviero ^[2] ; Josè Maria,Rojo ^[3] ; Silvia,Zucchelli ^[4] ; Francesca,Persichetti ^[1] ; Gianluca,Baldanzi ^[2] ; Umberto,Dianzani ^[3] ; Davide,Corà ^[5]

作者单位： Department of Health Sciences, University of Piemonte Orientale, Novara, Italy. ^[1] Interdisciplinary Research Center of Autoimmune Diseases (IRCAD), University of Piemonte Orientale, Novara, Italy. ^[2] CAAD - Center for Translational Research on Autoimmune and Allergic Disease, Novara, Italy. ^[3] Department of Molecular Genetics, Groningen Biomolecular Sciences and Biotechnology Institute (GBB), University of Groningen, Groningen, Netherlands. ^[4] Dipartimento di Scienze della Vita e Biologia dei Sistemi, Università di Torino, Torino, Italy. ^[5] Italian Institute for Genomic Medicine (IIGM), Torino, Italy. ^[6] Centro de Investigaciones Biológicas Margarita Salas, Consejo Superior de Investigaciones Cientificas (CSIC), Madrid, Spain. ^[7] Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy. ^[8] Biochemical Chemistry, "Maggiore della Carità" University Hospital, Novara, Italy. ^[9]

关键词 CD28 ICOS RNA sequencing T-cell receptor human CD4+ T cells

主题词 CD4阳性T淋巴细胞(CD4-Positive T-Lymphocytes);胆固醇(Cholesterol);葡糖氨基聚糖类(Glycosaminoglycans);人类(Humans);受体, 抗原, T细胞(Receptors, Antigen, T-Cell);转录, 遗传(Transcription, Genetic);p38丝裂原活化蛋白激酶类(p38 Mitogen-Activated Protein Kinases)

DOI 10.3389/fimmu.2022.915963

PMID 36131938

发布时间 2022-09-29

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