换一批
第一作者：
Adam M,Staffaroni
第一单位：
Department of Neurology, Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA. adam.staffaroni@ucsf.edu.
作者：
Adam M,Staffaroni [1]
;
Melanie,Quintana [2]
;
Barbara,Wendelberger [2]
;
Hilary W,Heuer [3]
;
Lucy L,Russell [4]
;
Yann,Cobigo [3]
;
Amy,Wolf [3]
;
Sheng-Yang Matt,Goh [3]
;
Leonard,Petrucelli [5]
;
Tania F,Gendron [5]
;
Carolin,Heller [4]
;
Annie L,Clark [3]
;
Jack Carson,Taylor [3]
;
Amy,Wise [3]
;
Elise,Ong [3]
;
Leah,Forsberg [6]
;
Danielle,Brushaber [7]
;
Julio C,Rojas [3]
;
Lawren,VandeVrede [3]
;
Peter,Ljubenkov [3]
;
Joel,Kramer [3]
;
Kaitlin B,Casaletto [3]
;
Brian,Appleby [8]
;
Yvette,Bordelon [9]
;
Hugo,Botha [6]
;
Bradford C,Dickerson [10]
;
Kimiko,Domoto-Reilly [11]
;
Julie A,Fields [12]
;
Tatiana,Foroud [13]
;
Ralitza,Gavrilova [6]
;
Daniel,Geschwind [14]
;
Nupur,Ghoshal [15]
;
Jill,Goldman [16]
;
Jonathon,Graff-Radford [6]
;
Neill,Graff-Radford [17]
;
Murray,Grossman [18]
;
Matthew G H,Hall [3]
;
Ging-Yuek,Hsiung [19]
;
Edward D,Huey [16]
;
David,Irwin [18]
;
David T,Jones [6]
;
Kejal,Kantarci [6]
;
Daniel,Kaufer [20]
;
David,Knopman [6]
;
Walter,Kremers [7]
;
Argentina Lario,Lago [3]
;
Maria I,Lapid [12]
;
Irene,Litvan [21]
;
Diane,Lucente [10]
;
Ian R,Mackenzie [22]
;
Mario F,Mendez [9]
;
Carly,Mester [7]
;
Bruce L,Miller [3]
;
Chiadi U,Onyike [23]
;
Rosa,Rademakers [24]
;
Vijay K,Ramanan [6]
;
Eliana Marisa,Ramos [9]
;
Meghana,Rao [6]
;
Katya,Rascovsky [18]
;
Katherine P,Rankin [3]
;
Erik D,Roberson [25]
;
Rodolfo,Savica [6]
;
M Carmela,Tartaglia [26]
;
Sandra,Weintraub [27]
;
Bonnie,Wong [10]
;
David M,Cash [4]
;
Arabella,Bouzigues [4]
;
Imogen J,Swift [4]
;
Georgia,Peakman [4]
;
Martina,Bocchetta [4]
;
Emily G,Todd [4]
;
Rhian S,Convery [4]
;
James B,Rowe [28]
;
Barbara,Borroni [29]
;
Daniela,Galimberti [30]
;
Pietro,Tiraboschi [31]
;
Mario,Masellis [32]
;
Elizabeth,Finger [33]
;
John C,van Swieten [34]
;
Harro,Seelaar [34]
;
Lize C,Jiskoot [34]
;
Sandro,Sorbi [35]
;
Chris R,Butler [36]
;
Caroline,Graff [37]
;
Alexander,Gerhard [38]
;
Tobias,Langheinrich [39]
;
Robert,Laforce [40]
;
Raquel,Sanchez-Valle [41]
;
Alexandre,de Mendonça [42]
;
Fermin,Moreno [43]
;
Matthis,Synofzik [44]
;
Rik,Vandenberghe [45]
;
Simon,Ducharme [46]
;
Isabelle,Le Ber [47]
;
Johannes,Levin [48]
;
Adrian,Danek [49]
;
Markus,Otto [50]
;
Florence,Pasquier [51]
;
Isabel,Santana [52]
;
John,Kornak [53]
;
Bradley F,Boeve [6]
;
Howard J,Rosen [3]
;
Jonathan D,Rohrer [4]
;
Adam L,Boxer [54]
;
Frontotemporal Dementia Prevention Initiative (FPI) Investigators
作者单位：
Department of Neurology, Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA. adam.staffaroni@ucsf.edu.
[1]
Berry Consultants, Austin, TX, USA.
[2]
Department of Neurology, Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.
[3]
Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square London, London, UK.
[4]
Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
[5]
Department of Neurology, Mayo Clinic, Rochester, MN, USA.
[6]
Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
[7]
Department of Neurology, Case Western Reserve University, Cleveland, OH, USA.
[8]
Department of Neurology, University of California, Los Angeles, Los Angeles, USA.
[9]
Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
[10]
Department of Neurology, University of Washington, Seattle, WA, USA.
[11]
Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.
[12]
Indiana University School of Medicine, National Centralized Repository for Alzheimer's, Indianapolis, IN, USA.
[13]
Department of Neurology, University of California, Los Angeles, Los Angeles, USA.;Institute for Precision Health, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
[14]
Departments of Neurology and Psychiatry, Washington University School of Medicine, Washington University, St. Louis, MO, USA.
[15]
Department of Neurology, Columbia University, New York, NY, USA.
[16]
Department of Neurology, Mayo Clinic, Jacksonville, FL, USA.
[17]
Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA.
[18]
Division of Neurology, University of British Columbia, Vancouver, British Columbia, Canada.
[19]
Department of Neurology, University of North Carolina, Chapel Hill, NC, USA.
[20]
Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
[21]
Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada.
[22]
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.
[23]
Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.;Applied and Translational Neurogenomics Group, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.;Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.
[24]
Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA.
[25]
Tanz Centre for Research in Neurodegenerative Diseases, Division of Neurology, University of Toronto, Toronto, Ontario, Canada.
[26]
Department of Neurology, Northwestern University, Chicago, IL, USA.
[27]
Department of Clinical Neurosciences and Cambridge University Hospitals NHS Trust and Medical Research Council Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK.
[28]
Centre for Neurodegenerative Disorders, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
[29]
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy.;Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.
[30]
Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy.
[31]
Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre; Hurvitz Brain Sciences Program, Sunnybrook Research Institute, University of Toronto, Toronto, Ontario, Canada.
[32]
Department of Clinical Neurological Sciences, University of Western Ontario, London, Ontario, Canada.
[33]
Department of Neurology, Erasmus Medical Centre, Rotterdam, Netherlands.
[34]
Department of Neurofarba, University of Florence, Florence, Italy.;IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy.
[35]
Nuffield Department of Clinical Neurosciences, Medical Sciences Division, University of Oxford, Oxford, UK.;Department of Brain Sciences, Imperial College London, London, UK.
[36]
Center for Alzheimer Research, Division of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Bioclinicum, Karolinska Institutet, Solna, Sweden.;Unit for Hereditary Dementias, Theme Aging, Karolinska University Hospital, Solna, Sweden.
[37]
Division of Neuroscience and Experimental Psychology, Wolfson Molecular Imaging Centre, University of Manchester, Manchester, UK.;Departments of Geriatric Medicine and Nuclear Medicine, Center for Translational Neuro- and Behavioral Sciences, University Medicine Essen, Essen, Germany.
[38]
Division of Neuroscience and Experimental Psychology, Wolfson Molecular Imaging Centre, University of Manchester, Manchester, UK.;Cerebral Function Unit, Manchester Centre for Clinical Neurosciences, Salford Royal NHS Foundation Trust, Salford, UK.
[39]
Clinique Interdisciplinaire de Mémoire, Département des Sciences Neurologiques, CHU de Québec, and Faculté de Médecine, Université Laval, Québec City, Québec, Canada.
[40]
Alzheimer's disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Clínic, Institut d'Investigacións Biomèdiques August Pi I Sunyer, University of Barcelona, Barcelona, Spain.
[41]
Faculty of Medicine, University of Lisbon, Lisbon, Portugal.
[42]
Cognitive Disorders Unit, Department of Neurology, Donostia University Hospital, San Sebastian, Gipuzkoa, Spain.;Neuroscience Area, Biodonostia Health Research Institute, San Sebastian, Gipuzkoa, Spain.
[43]
Department of Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research and Center of Neurology, University of Tübingen, Tübingen, Germany.;Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.
[44]
Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Leuven, Belgium.;Neurology Service, University Hospitals Leuven, Leuven, Belgium.;Leuven Brain Institute, KU Leuven, Leuven, Belgium.
[45]
Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Canada.;McConnell Brain Imaging Centre, Montreal Neurological Institute, Department of Neurology & Neurosurgery, McGill University, Montreal, Québec, Canada.
[46]
Sorbonne Université, Paris Brain Institute - Institut du Cerveau - ICM, Inserm U1127, CNRS UMR 7225, AP-HP - Hôpital Pitié-Salpêtrière, Paris, France.;Centre de référence des démences rares ou précoces, IM2A, Département de Neurologie, AP-HP - Hôpital Pitié-Salpêtrière, Paris, France.;Département de Neurologie, AP-HP - Hôpital Pitié-Salpêtrière, Paris, France.
[47]
Neurologische Klinik und Poliklinik, Ludwig-Maximilians-Universität, Munich, Germany.;Center for Neurodegenerative Diseases (DZNE), Munich, Germany.;Munich Cluster of Systems Neurology, Munich, Germany.
[48]
Neurologische Klinik und Poliklinik, Ludwig-Maximilians-Universität, Munich, Germany.
[49]
Department of Neurology, University of Ulm, Ulm, Germany.
[50]
University of Lille, Lille, France.;Inserm, Lille, France.;CHU, CNR-MAJ, Labex Distalz, LiCEND Lille, Lille, France.
[51]
Neurology Service, Faculty of Medicine, University Hospital of Coimbra (HUC), University of Coimbra, Coimbra, Portugal.;Center for Neuroscience and Cell Biology, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
[52]
Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA.
[53]
Department of Neurology, Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA. adam.boxer@ucsf.edu.
[54]
医学主题词
临床试验(主题)(Clinical Trials as Topic);疾病恶化(Disease Progression);额颞叶痴呆(Frontotemporal Dementia);人类(Humans);突变(Mutation);tau蛋白质类(tau Proteins)
DOI
10.1038/s41591-022-01942-9
PMID
36138153
发布时间
2025-05-30
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Nature medicine
Nature medicine
2194-2206页
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