首页> Brain sciences> LRRK2 Deficiency Aggravates Sleep Deprivation-Induced Cognitive Loss by Perturbing Synaptic Pruning in Mice.

LRRK2 Deficiency Aggravates Sleep Deprivation-Induced Cognitive Loss by Perturbing Synaptic Pruning in Mice.

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第一作者： Xiaojuan,Cheng

第一单位： Department of Neurology, Center for Cognitive Neurology, Institute of Clinical Neurology, Fujian Medical University Union Hospital, Fuzhou 350001, China.;Fujian Institute of Geriatrics, Fujian Medical University Union Hospital, Fuzhou 350001, China.;Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou 350001, China.;Key Laboratory of Brain Aging and Neurodegenerative Diseases, Fujian Medical University, Fuzhou 350001, China.

作者： Xiaojuan,Cheng ^[1] ; Xilin,Wu ^[1] ; Yuying,Zhang ^[2] ; Weian,Li ^[3] ; Linjuan,Feng ^[1] ; Hanlin,You ^[1] ; Siyu,Yang ^[2] ; Dongping,Yang ^[4] ; Xiaochun,Chen ^[2] ; Xiaodong,Pan ^[1]

作者单位： Department of Neurology, Center for Cognitive Neurology, Institute of Clinical Neurology, Fujian Medical University Union Hospital, Fuzhou 350001, China.;Fujian Institute of Geriatrics, Fujian Medical University Union Hospital, Fuzhou 350001, China.;Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou 350001, China.;Key Laboratory of Brain Aging and Neurodegenerative Diseases, Fujian Medical University, Fuzhou 350001, China. ^[1] Department of Neurology, Center for Cognitive Neurology, Institute of Clinical Neurology, Fujian Medical University Union Hospital, Fuzhou 350001, China.;Fujian Institute of Geriatrics, Fujian Medical University Union Hospital, Fuzhou 350001, China.;Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou 350001, China. ^[2] School of Advanced Manufacturing, Fuzhou University, Fuzhou 350108, China. ^[3] Research Institute of Artificial Intelligence, Zhejiang Laboratory, Hangzhou 310027, China. ^[4]

关键词 LRRK2 deficiency REM/NREM microglial synaptic pruning sleep deprivation

DOI 10.3390/brainsci12091200

PMID 36138936

发布时间 2022-09-28

基金项目

82071175/National Natural Science Foundation of China 81901072/National Natural Science Foundation of China 2020J02022/Natural Science Foundation (Key Project) of Fujian Province

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2022年12卷9期

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LRRK2 Deficiency Aggravates Sleep Deprivation-Induced Cognitive Loss by Perturbing Synaptic Pruning in Mice.

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LRRK2 Deficiency Aggravates Sleep Deprivation-Induced Cognitive Loss by Perturbing Synaptic Pruning in Mice.

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