Predicting Egg Passage Adaptations to Design Better Vaccines for the H3N2 Influenza Virus.

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第一作者： Yunsong,Liu

第一单位： Key Laboratory of Zoological Systematics and Evolution, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.;University of the Chinese Academy of Sciences, Beijing 100049, China.

作者： Yunsong,Liu ^[1] ; Hui,Chen ^[2] ; Wenyuan,Duan ^[1] ; Xinyi,Zhang ^[1] ; Xionglei,He ^[3] ; Rasmus,Nielsen ^[4] ; Liang,Ma ^[5] ; Weiwei,Zhai ^[6]

作者单位： Key Laboratory of Zoological Systematics and Evolution, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.;University of the Chinese Academy of Sciences, Beijing 100049, China. ^[1] Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore 138672, Singapore. ^[2] MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China. ^[3] Department of Integrative Biology, University of California-Berkeley, Berkeley, CA 94707, USA.;Department of Statistics, University of California-Berkeley, Berkeley, CA 94707, USA.;Globe Institute, University of Copenhagen, 1350 København, Copenhagen, Denmark. ^[4] Key Laboratory of Zoological Systematics and Evolution, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China. ^[5] Key Laboratory of Zoological Systematics and Evolution, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.;University of the Chinese Academy of Sciences, Beijing 100049, China.;Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming 650223, China. ^[6]

关键词 H3N2 influenza convergent evolution epistasis fitness landscape passage adaptation vaccine efficacy

主题词血凝素糖蛋白类, 流感病毒(Hemagglutinin Glycoproteins, Influenza Virus);血凝素类(Hemagglutinins);人类(Humans);流感病毒A型, H3N2亚型(Influenza A Virus, H3N2 Subtype);流感疫苗(Influenza Vaccines);流感, 人(Influenza, Human)

DOI 10.3390/v14092065

PMID 36146872

发布时间 2022-10-04

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