In silico investigation of nonsynonymous single nucleotide polymorphisms in BCL2 apoptosis regulator gene to design novel protein-based drugs against cancer.

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第一作者： Muhammad Mazhar,Fareed

第一单位： Department of Computer Science, School of Science and Engineering, Università degli studi di Verona, Verona, Italy.

作者： Muhammad Mazhar,Fareed ^[1] ; Kunal,Dutta ^[2] ; Thomas,Dandekar ^[3] ; Herman,Tarabonda ^[4] ; Ekaterina V,Skorb ^[4] ; Sergey,Shityakov ^[4]

作者单位： Department of Computer Science, School of Science and Engineering, Università degli studi di Verona, Verona, Italy. ^[1] Department of Human Physiology, Vidyasagar University, Midnapore, West Bengal, India. ^[2] Department of Bioinformatics, Biocenter, University of Würzburg, Würzburg, Germany. ^[3] Laboratory of Chemoinformatics, Infochemistry Scientific Center, ITMO University, Saint-Petersburg, Russia. ^[4]

关键词 Bcl-2 apoptosis regulator cancer molecular dynamics nonsynonymous single nucleotide polymorphisms posttranslational modifications protein-based inhibitors

主题词人类(Humans);多态性, 单核苷酸(Polymorphism, Single Nucleotide);细胞凋亡(Apoptosis);肿瘤(Neoplasms);原癌基因蛋白质c-bcl-2(Proto-Oncogene Proteins c-bcl-2);基因, 调节(Genes, Regulator);计算生物学(Computational Biology)

DOI 10.1002/jcb.30330

PMID 36146908

发布时间 2022-12-23

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