首页> Journal of pharmaceutical and biomedical analysis> Development and validation of a bioanalytical method for the quantification of axitinib from plasma and capillary blood using volumetric absorptive microsampling (VAMS) and on-line solid phase extraction (SPE) LC-MS.

Development and validation of a bioanalytical method for the quantification of axitinib from plasma and capillary blood using volumetric absorptive microsampling (VAMS) and on-line solid phase extraction (SPE) LC-MS.

导出 LinkOut

翻译打印收藏纠错

第一作者： Patrick,Opitz

第一单位： Department of Pharmaceutical and Medical Chemistry, Clinical Pharmacy, University of Muenster, Muenster, Germany.

作者： Patrick,Opitz ^[1] ; Sebastian,Zimmermann ^[2] ; Anna M,Mc Laughlin ^[3] ; Lothar,Müller ^[4] ; Stefan,Fuxius ^[5] ; Gerald,Illerhaus ^[6] ; Oliver,Scherf-Clavel ^[2] ; Charlotte,Kloft ^[7] ; Georg,Hempel ^[8] ; ON-TARGET study consortium

作者单位： Department of Pharmaceutical and Medical Chemistry, Clinical Pharmacy, University of Muenster, Muenster, Germany. ^[1] Institute of Pharmacy and Food Chemistry, Julius-Maximilians-Universität Würzburg, Würzburg, Germany. ^[2] Department of Clinical Pharmacy and Biochemistry, Institute of Pharmacy, Freie Universität Berlin, Berlin, Germany; Graduate Research Training Program PharMetrX, Berlin/Potsdam, Germany. ^[3] Onkologie UnterEms, Leer, Germany. ^[4] Onkologische Schwerpunktpraxis Heidelberg, Heidelberg, Germany. ^[5] Klinik für Hämatologie, Onkologie, und Palliativmedizin, Klinikum Stuttgart, Stuttgart, Germany. ^[6] Department of Clinical Pharmacy and Biochemistry, Institute of Pharmacy, Freie Universität Berlin, Berlin, Germany. ^[7] Department of Pharmaceutical and Medical Chemistry, Clinical Pharmacy, University of Muenster, Muenster, Germany. Electronic address: georg.hempel@uni-muenster.de. ^[8]

关键词 On-line SPE-LC-MS Renal cell carcinoma Therapeutic drug monitoring (TDM)Trap technology Tyrosin kinase inhibitor (TKI)Volumetric absorptive microsampling (VAMS)

医学主题词乙腈类(Acetonitriles);色谱法, 液相(Chromatography, Liquid);固相萃取(Solid Phase Extraction);串联质谱法(Tandem Mass Spectrometry);水(Water)

DOI 10.1016/j.jpba.2022.115033

PMID 36148722

发布时间 2022-10-13

翻译满意度评价：

准确一般字义偏差语意偏离译文作用小提交