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Effect of RNS60 in amyotrophic lateral sclerosis: a phase II multicentre, randomized, double-blind, placebo-controlled trial.

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第一作者: Ettore,Beghi
第一单位: Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milano, Italy.
作者单位: Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milano, Italy. [1] Neurological Clinical Research Institute, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA. [2] Sean M. Healey and AMG Center for ALS at Mass General Hospital, Department of Neurology, Boston, Massachusetts, USA. [3] Spaulding Rehabilitation Hospital, Department of PM&R, Harvard Medical School, Boston, Massachusetts, USA. [4] ALS Expert Center 'Maggiore della Carità' Hospital and University of Piemonte Orientale, Novara, Italy. [5] Spinal Cord Injuries Section, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy. [6] Institute of Clinical Physiology, CNR-, Pisa, Italy. [7] IRCCS Ospedale Policlinico San Martino, Genoa, Italy. [8] IRCCS Mondino Foundation, Pavia, Italy. [9] Centro Regionale Esperto per la Sclerosi Laterale Amiotrofica, Dipartimento di Neuroscienze 'Rita Levi Montalcini', Università degli Studi di Torino, AOU Città della Salute e della Scienza di Torino, Torino, Italy. [10] Department of Clinical and Experimental Sciences, University of Brescia, Gussago Brescia, Italy. [11] Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy. [12] Università di Roma 'Sapienza' UOSD Malattie Neurodegenerative, Centro Malattie Rare Neuromuscolari Policlinico Universitario Umberto I, Roma, Italy. [13] ALS Clinical Research Center, AOUP 'P Giaccone' - University of Palermo, Palermo, Italy. [14] Center for neurodegenerative diseases and the Aging Brain, Department of Clinical Research in Neurology of the University of Bari at 'Pia Fondazione Card G. Panico 'Hospital Tricase, Tricase, Italy. [15] Department of Basic Medicine Neuroscience and Sense Organs, University Aldo Moro Bari, Bari, Italy. [16] Centro Clinico NeMO Milano, Fondazione Serena ONLUS, Milan, Italy. [17] Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy. [18] Department of Neurosciences, Azienda Ospedaliero-Universitaria Di Modena, Modena, Italy. [19] Clinical and Experimental Medicine PhD Program, University of Modena and Reggio Emilia, Modena, Italy. [20] Neuroscience PhD Program, University of Modena and Reggio Emilia, Modena, Italy. [21] Department of Advanced Medical and Surgical Sciences, University of Campania 'Luigi Vanvitelli', Naples, Italy. [22] Neurology Unit, Neurorehabilitation Unit, and Neurophysiology Unit, Vita-Salute San Raffaele University and San Raffaele Scientific Institute, Milan, Italy. [23] Neurology Unit, Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari, Bari, Italy. [24] Motor Neuton Disease Center, Department of Neurosciences, Azienda Ospedale Università di Padova, Padova, Italy. [25] Azienda Ospedaliera 'S Maria' Terni, Terni, Italy. [26] Neurology Department, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy. [27] Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy. [28] Department of clinical and experimental medicine, University of Pisa, Pisa, Italy. [29] Centro Clinico NEMO-Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy. [30] Neurology Department, San Francesco Hospital, Nuoro, Italy. [31]
DOI 10.1111/ene.15573
PMID 36148821
发布时间 2023-04-15
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