Evolution of the <i>vls</i> Antigenic Variability Locus of the Lyme Disease Pathogen and Development of Recombinant Monoclonal Antibodies Targeting Conserved VlsE Epitopes.

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作者： Li,Li ^[1] ; Lia,Di ^[2] ; Saymon,Akther ^[1] ; Brian M,Zeglis ^[3] ; Weigang,Qiu ^[4]

作者单位： Graduate Center, City University of New York, New York, New York, USA. ^[1] Department of Biological Sciences, Hunter Collegegrid.257167.0, City University of New York, New York, New York, USA. ^[2] Graduate Center, City University of New York, New York, New York, USA.;Department of Chemistry, Hunter Collegegrid.257167.0, City University of New York, New York, New York, USA.;Department of Radiology, Weill Cornell Medical College, New York, New York, USA.;Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York, USA. ^[3] Graduate Center, City University of New York, New York, New York, USA.;Department of Biological Sciences, Hunter Collegegrid.257167.0, City University of New York, New York, New York, USA.;Department of Physiology and Biophysics, Weill Cornell Medical College, New York, New York, USA.;Institute for Computational Biomedicine, Weill Cornell Medical College, New York, New York, USA. ^[4]

关键词 Borrelia burgdorferi C6 peptide Lyme disease VlsE monoclonal antibodies

主题词人类(Humans);兔(Rabbits);动物(Animals);伯氏疏螺旋体(Borrelia burgdorferi);表位(Epitopes);抗原, 细菌(Antigens, Bacterial);抗体, 单克隆(Antibodies, Monoclonal);脂蛋白类(Lipoproteins);细菌蛋白质类(Bacterial Proteins);莱姆病(Lyme Disease);抗原变异(Antigenic Variation);膜蛋白质类(Membrane Proteins);肽类(Peptides);抗体, 细菌(Antibodies, Bacterial);哺乳动物(Mammals)

DOI 10.1128/spectrum.01743-22

PMID 36150043

发布时间 2024-09-27

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Microbiology spectrum

2022年10卷5期

e0174322页

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Evolution of the <i>vls</i> Antigenic Variability Locus of the Lyme Disease Pathogen and Development of Recombinant Monoclonal Antibodies Targeting Conserved VlsE Epitopes.

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Evolution of the <i>vls</i> Antigenic Variability Locus of the Lyme Disease Pathogen and Development of Recombinant Monoclonal Antibodies Targeting Conserved VlsE Epitopes.

Microbiology spectrum

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Microbiology spectrum

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