Guanidino quinazolines and pyrimidines promote readthrough of premature termination codons in cells with native nonsense mutations.

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作者： Christie,Morrill ^[1] ; Westley J,Friesen ^[2] ; Suresh,Babu ^[2] ; Ramil Y,Baiazitov ^[2] ; Wu,Du ^[2] ; Diane B,Karloff ^[2] ; Chang-Sun,Lee ^[2] ; Young-Choon,Moon ^[2] ; Hongyu,Ren ^[2] ; Jairo,Sierra ^[2] ; Yuki,Tomizawa ^[2] ; Priya,Vazirani ^[2] ; Ellen M,Welch ^[2] ; Xiaojiao,Xue ^[2] ; Jin,Zhuo ^[2]

作者单位： PTC Therapeutics, Inc., 100 Corporate Court, South Plainfield, NJ 07080, USA. Electronic address: cmorrill@ptcbio.com. ^[1] PTC Therapeutics, Inc., 100 Corporate Court, South Plainfield, NJ 07080, USA. ^[2]

关键词 Guanidine Myotube Nonsense mutation Premature termination codon Readthrough

主题词密码子, 无义(Codon, Nonsense);喹唑啉类(Quinazolines);嘧啶类(Pyrimidines);胍类(Guanidines);氮(Nitrogen);胺类(Amines)

DOI 10.1016/j.bmcl.2022.128989

PMID 36150638

发布时间 2022-10-27

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准确一般字义偏差语意偏离译文作用小提交