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Wild-type IDH1 inhibition enhances chemotherapy response in melanoma.

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第一作者： Mehrdad,Zarei

第一单位： Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA.;Department of Surgery, Division of Surgical Oncology, University Hospitals Cleveland Medical Center, 11100 Euclid Ave., Cleveland, OH, 44106, USA.

作者： Mehrdad,Zarei ^[1] ; Omid,Hajihassani ^[2] ; Jonathan J,Hue ^[3] ; Hallie J,Graor ^[2] ; Alexander W,Loftus ^[3] ; Moeez,Rathore ^[2] ; Ali,Vaziri-Gohar ^[2] ; John M,Asara ^[4] ; Jordan M,Winter ^[5] ; Luke D,Rothermel ^[6]

作者单位： Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA.;Department of Surgery, Division of Surgical Oncology, University Hospitals Cleveland Medical Center, 11100 Euclid Ave., Cleveland, OH, 44106, USA. ^[1] Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA. ^[2] Department of Surgery, Division of Surgical Oncology, University Hospitals Cleveland Medical Center, 11100 Euclid Ave., Cleveland, OH, 44106, USA. ^[3] Division of Signal Transduction and Mass Spectrometry Core, Beth Israel Deaconess Medical Center, Boston, MA, USA.;Department of Medicine, Harvard Medical School, Boston, MA, USA. ^[4] Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA. Jordan.Winter@UHHospitals.org.;Department of Surgery, Division of Surgical Oncology, University Hospitals Cleveland Medical Center, 11100 Euclid Ave., Cleveland, OH, 44106, USA. Jordan.Winter@UHHospitals.org. ^[5] Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA. Luke.Rothermel@UHHospitals.org.;Department of Surgery, Division of Surgical Oncology, University Hospitals Cleveland Medical Center, 11100 Euclid Ave., Cleveland, OH, 44106, USA. Luke.Rothermel@UHHospitals.org. ^[6]

关键词 Chemoresistance Combination therapy IDH1 Ivosidenib Melanoma