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Integrating peripheral blood and brain transcriptomics to identify immunological features associated with Alzheimer's disease in mild cognitive impairment patients.

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第一作者： Xiao-Hang,Qian

第一单位： Department of Neurology and Institute of Neurology, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

作者： Xiao-Hang,Qian ^[1] ; Xiao-Li,Liu ^[2] ; Sheng-di,Chen ^[1] ; Hui-Dong,Tang ^[3]

作者单位： Department of Neurology and Institute of Neurology, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ^[1] Department of Neurology, Shanghai Fengxian District Central Hospital, Shanghai Jiao Tong University Affiliated Sixth People's Hospital South Campus, Shanghai, China. ^[2] Department of Neurology and Institute of Neurology, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.;Medical Center on Aging of Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ^[3]

关键词 Alzheimer’s disease HSP90AA1 RELA immune hub gene mild cognitive impairment peripheral immune cells

医学主题词阿尔茨海默病(Alzheimer Disease);淀粉样前体蛋白分泌酶类(Amyloid Precursor Protein Secretases);脑(Brain);半胱氨酸天冬氨酸蛋白酶3(Caspase 3);人类(Humans);NF-κB(NF-kappa B)

DOI 10.3389/fimmu.2022.986346

PMID 36159817

发布时间 2022-09-28

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