Stabilization of hypoxia-inducible factor-1α alleviates osteoarthritis via interacting with Per2 and resetting the circadian clock.

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第一作者： Chenzhong,Wang

第一单位： Department of Orthopedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, PR China.

作者： Chenzhong,Wang ^[1] ; Yueqi,Zhang ^[1] ; Zhe,Wang ^[1] ; Wei,Yu ^[1] ; Minji,Tong ^[1] ; Zuoqin,Yan ^[2]

作者单位： Department of Orthopedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, PR China. ^[1] Department of Orthopedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, PR China. Electronic address: yan.zuoqin@zs-hospital.sh.cn. ^[2]

关键词 Cartilage Circadian clock HIF1alpha Osteoarthritis

主题词人类(Humans);昼夜节律钟(Circadian Clocks);飞行时差反应综合征(Jet Lag Syndrome);缺氧诱导因子1, α亚基(Hypoxia-Inducible Factor 1, alpha Subunit);骨关节炎(Osteoarthritis);氧(Oxygen);周期昼夜节律蛋白质类(Period Circadian Proteins)

DOI 10.1016/j.tice.2022.101942

PMID 36162153

发布时间 2022-11-22

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