首页> Military Medical Research> Melatonin inhibits ESCC tumor growth by mitigating the HDAC7/β-catenin/c-Myc positive feedback loop and suppressing the USP10-maintained HDAC7 protein stability.

Melatonin inhibits ESCC tumor growth by mitigating the HDAC7/β-catenin/c-Myc positive feedback loop and suppressing the USP10-maintained HDAC7 protein stability.

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第一作者： Zhi-Qiang,Ma

第一单位： Department of Medical Oncology, Senior Department of Oncology, the Fifth Medical Center, Chinese PLA General Hospital, Beijing, 100853, China.;Department of Thoracic Surgery, Tangdu Hospital, the Fourth Military Medical University, Xi'an, 710038, China.

作者： Zhi-Qiang,Ma ^[1] ; Ying-Tong,Feng ^[2] ; Kai,Guo ^[3] ; Dong,Liu ^[4] ; Chang-Jian,Shao ^[5] ; Ming-Hong,Pan ^[5] ; Yi-Meng,Zhang ^[6] ; Yu-Xi,Zhang ^[7] ; Di,Lu ^[8] ; Di,Huang ^[8] ; Fan,Zhang ^[8] ; Jin-Liang,Wang ^[8] ; Bo,Yang ^[8] ; Jing,Han ^[9] ; Xiao-Long,Yan ^[10] ; Yi,Hu ^[11]

作者单位： Department of Medical Oncology, Senior Department of Oncology, the Fifth Medical Center, Chinese PLA General Hospital, Beijing, 100853, China.;Department of Thoracic Surgery, Tangdu Hospital, the Fourth Military Medical University, Xi'an, 710038, China. ^[1] Department of Thoracic Surgery, Tangdu Hospital, the Fourth Military Medical University, Xi'an, 710038, China.;Department of Cardiothoracic Surgery, the 71th Group Army Hospital of PLA, the Affiliated Huaihai Hospital of Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China. ^[2] Department of Thoracic Surgery, Tangdu Hospital, the Fourth Military Medical University, Xi'an, 710038, China.;Department of Thoracic Surgery, Shaanxi Provincial People's Hospital, the Third Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710068, China. ^[3] State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100037, China. ^[4] Department of Thoracic Surgery, Tangdu Hospital, the Fourth Military Medical University, Xi'an, 710038, China. ^[5] Department of Ophthalmology, Tangdu Hospital, the Fourth Military Medical University, Xi'an, 710038, China. ^[6] Department of Cardiovascular Surgery, Xijing Hospital, the Fourth Military Medical University, Xi'an, 710032, China. ^[7] Department of Medical Oncology, Senior Department of Oncology, the Fifth Medical Center, Chinese PLA General Hospital, Beijing, 100853, China. ^[8] Department of Ophthalmology, Tangdu Hospital, the Fourth Military Medical University, Xi'an, 710038, China. hanjing@fmmu.edu.cn. ^[9] Department of Thoracic Surgery, Tangdu Hospital, the Fourth Military Medical University, Xi'an, 710038, China. yanxiaolong@fmmu.edu.cn. ^[10] Department of Medical Oncology, Senior Department of Oncology, the Fifth Medical Center, Chinese PLA General Hospital, Beijing, 100853, China. huyi301zlxb@sina.com. ^[11]

关键词 Esophageal squamous cell carcinoma?(ESCC)Histone deacetylase 7 (HDAC7)Melatonin Ubiquitin-specific peptidase 10 (USP10)c-Myc β-catenin