Asebogenin suppresses thrombus formation via inhibition of Syk phosphorylation.

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第一作者： Li,Li

第一单位： Department of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

作者： Li,Li ^[1] ; Xulin,Xu ^[1] ; Keyu,Lv ^[1] ; Guijuan,Zheng ^[2] ; Hao,Wang ^[1] ; Shuai,Chen ^[1] ; Lang,Huang ^[2] ; Yi,Liu ^[3] ; Yadong,Zhang ^[3] ; Zhaoming,Tang ^[4] ; Lili,Zhang ^[1] ; Jinyu,Wang ^[5] ; Jianlin,Qiao ^[6] ; Hongliang,Li ^[7] ; Xuanbin,Wang ^[8] ; Guangmin,Yao ^[9] ; Chao,Fang ^[8]

作者单位： Department of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. ^[1] Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. ^[2] DeepKinase Biotechnologies Ltd., Beijing, China. ^[3] Department of Clinical Laboratory, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. ^[4] School of Stomatology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. ^[5] The Key Laboratory of Oral and Maxillofacial Development and Regeneration of Hubei Province, Wuhan, Hubei, China. ^[6] Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China. ^[7] Laboratory of Chinese Herbal Pharmacology, Department of Pharmacy, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei, China. ^[8] Biomedical Research Institute, School of Pharmaceutical Sciences and Hubei Key Laboratory of Wudang Local Chinese Medicine Research, Hubei University of Medicine, Shiyan, Hubei, China. ^[9] The Key Laboratory for Drug Target Researches and Pharmacodynamic Evaluation of Hubei Province, Wuhan, Hubei, China. ^[10]

关键词 asebogenin neutrophil extracellular traps platelet activation spleen tyrosine kinase thrombus formation