Cancer cells produce liver metastasis via gap formation in sinusoidal endothelial cells through proinflammatory paracrine mechanisms.

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作者： Truong,Huu Hoang ^[1] ; Misako,Sato-Matsubara ^[2] ; Hideto,Yuasa ^[1] ; Tsutomu,Matsubara ^[3] ; Le Thi Thanh,Thuy ^[4] ; Hiroko,Ikenaga ^[4] ; Dong Minh,Phuong ^[1] ; Ngo Vinh,Hanh ^[1] ; Vu Ngoc,Hieu ^[1] ; Dinh Viet,Hoang ^[1] ; Hoang,Hai ^[1] ; Yoshinori,Okina ^[5] ; Masaru,Enomoto ^[1] ; Akihiro,Tamori ^[1] ; Atsuko,Daikoku ^[1] ; Hayato,Urushima ^[1] ; Kazuo,Ikeda ^[4] ; Ninh Quoc,Dat ^[4] ; Yutaka,Yasui ^[4] ; Hiroji,Shinkawa ^[6] ; Shoji,Kubo ^[7] ; Ryota,Yamagishi ^[8] ; Naoko,Ohtani ^[8] ; Katsutoshi,Yoshizato ^[9] ; Jordi,Gracia-Sancho ^[9] ; Norifumi,Kawada ^[3]

作者单位： Department of Hepatology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan. ^[1] Department of Pain Medicine and Palliative Care, Cancer Institute, 108 Military Central Hospital, Hanoi, Vietnam. ^[2] Endowed Laboratory of Synthetic Biology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan. ^[3] Department of Anatomy and Regenerative Biology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan. ^[4] Department of Anesthesiology, Cho Ray Hospital, Ho Chi Minh City, Vietnam. ^[5] Department of Pediatrics, Hanoi Medical University, Hanoi, Vietnam. ^[6] Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Tokyo, Japan. ^[7] Department of Hepato-Biliary-Pancreatic Surgery, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan. ^[8] Department of Pathophysiology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan. ^[9] BioIntegrence Co. Ltd., Osaka, Japan. ^[10] Liver Vascular Biology Research Group, IDIBAPS Biomedical Research Institute, CIBEREHD, Barcelona, Spain. ^[11]

主题词肌动蛋白类(Actins);动物(Animals);多西环素(Doxycycline);内皮细胞(Endothelial Cells);人类(Humans);白细胞介素23(Interleukin-23);肝(Liver);肝肿瘤(Liver Neoplasms);基质金属蛋白酶2(Matrix Metalloproteinase 2);基质金属蛋白酶9(Matrix Metalloproteinase 9);小鼠(Mice);小鼠, 近交系(Mice, Inbred Strains);肿瘤坏死因子α(Tumor Necrosis Factor-alpha)

DOI 10.1126/sciadv.abo5525

PMID 36170363

发布时间 2022-10-14

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Science advances

2022年8卷39期

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Cancer cells produce liver metastasis via gap formation in sinusoidal endothelial cells through proinflammatory paracrine mechanisms.

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Cancer cells produce liver metastasis via gap formation in sinusoidal endothelial cells through proinflammatory paracrine mechanisms.

Science advances

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Science advances

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