Downregulation of ACE, AGTR1, and ACE2 genes mediating SARS-CoV-2 pathogenesis by gut microbiota members and their postbiotics on Caco-2 cells.

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作者： Sara,Ahmadi Badi ^[1] ; Amin,Malek ^[2] ; Alessandro,Paolini ^[3] ; Mahya,Rouhollahi Masoumi ^[4] ; Seyed Amirhesam,Seyedi ^[5] ; Amir,Amanzadeh ^[6] ; Andrea,Masotti ^[7] ; Shohreh,Khatami ^[8] ; Seyed Davar,Siadat ^[9]

作者单位： Microbiology Research Center, Pasteur Institute of Iran, Tehran, Iran; Mycobacteriology and Pulmonary Research Department, Pasteur Institute of Iran, Tehran, Iran. Electronic address: sarahmadi@gmail.com. ^[1] Microbiology Research Center, Pasteur Institute of Iran, Tehran, Iran; Mycobacteriology and Pulmonary Research Department, Pasteur Institute of Iran, Tehran, Iran. Electronic address: amin.malek73@yahoo.com. ^[2] Research Laboratories, Bambino Gesù Children's Hospital-IRCCS, Rome, Italy. Electronic address: alepaolini86@gmail.com. ^[3] Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran. Electronic address: mahya.r.m.1371@gmail.com. ^[4] Microbiology Research Center, Pasteur Institute of Iran, Tehran, Iran; Mycobacteriology and Pulmonary Research Department, Pasteur Institute of Iran, Tehran, Iran. Electronic address: amirhesam.seyyedi@gmail.com. ^[5] National Cell Bank of Iran, Pasteur Institute of Iran, Tehran, Iran. Electronic address: amir_amanzadeh@yahoo.com. ^[6] Research Laboratories, Bambino Gesù Children's Hospital-IRCCS, Rome, Italy. Electronic address: andrea.masotti@opbg.net. ^[7] Department of Biochemistry, Pasteur Institute of Iran, Tehran, Iran. Electronic address: sh-khatami@pasteur.ac.ir. ^[8] Microbiology Research Center, Pasteur Institute of Iran, Tehran, Iran; Mycobacteriology and Pulmonary Research Department, Pasteur Institute of Iran, Tehran, Iran. Electronic address: d.siadat@gmail.com. ^[9]

关键词 COVID-19 Gut microbiota Postbiotics Renin angiotensin system SARS-CoV2

主题词人类(Humans);Caco-2细胞(Caco-2 Cells);减量调节(Down-Regulation);微RNAs(MicroRNAs);受体, 血管紧张素, 1型(Receptor, Angiotensin, Type 1);肽基二肽酶A(Peptidyl-Dipeptidase A)

DOI 10.1016/j.micpath.2022.105798

PMID 36174833

发布时间 2022-12-21

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