首页> Immunology> Alternative pathway dysregulation in tissues drives sustained complement activation and predicts outcome across the disease course in COVID-19.

Alternative pathway dysregulation in tissues drives sustained complement activation and predicts outcome across the disease course in COVID-19.

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第一作者： Matthew K,Siggins

第一单位： National Heart & Lung Institute, Imperial College London, London, UK.

作者： Matthew K,Siggins ^[1] ; Kate,Davies ^[2] ; Rosie,Fellows ^[3] ; Ryan S,Thwaites ^[1] ; J Kenneth,Baillie ^[4] ; Malcolm G,Semple ^[5] ; Peter J M,Openshaw ^[1] ; Wioleta M,Zelek ^[2] ; Claire L,Harris ^[3] ; B Paul,Morgan ^[2] ; ISARIC4C Investigators

作者单位： National Heart & Lung Institute, Imperial College London, London, UK. ^[1] Division of Infection and Immunity and UK Dementia Research Institute Cardiff, Cardiff University, Cardiff, UK. ^[2] Translational & Clinical Research Institute, Newcastle University, Newcastle, UK. ^[3] Roslin Institute, University of Edinburgh, Edinburgh, UK. ^[4] NIHR Health Protection Research Unit, Institute of Infection, Veterinary, and Ecological Sciences, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, UK. ^[5]

关键词 COVID-19 alternative pathway biomarkers complement

医学主题词人类(Humans);补体激活(Complement Activation);补体系统蛋白质类(Complement System Proteins);补体C3b(Complement C3b);疾病恶化(Disease Progression);补体途径, 旁路(Complement Pathway, Alternative)

DOI 10.1111/imm.13585

PMID 36175370

发布时间 2023-03-22

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准确一般字义偏差语意偏离译文作用小提交