Establishment of a humanized animal model of systemic sclerosis in which T helper-17 cells from patients with systemic sclerosis infiltrate and cause fibrosis in the lungs and skin.
第一作者:
Min-Jung,Park
第一单位:
The Rheumatism Research Center, Catholic Research Institute of Medical Science, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
作者:
医学主题词
动物(Animals);博来霉素(Bleomycin);疾病模型, 动物(Disease Models, Animal);纤维化(Fibrosis);人类(Humans);炎症(Inflammation);白细胞介素17(Interleukin-17);白细胞, 单核(Leukocytes, Mononuclear);肺(Lung);小鼠(Mice);小鼠, 近交NOD(Mice, Inbred NOD);小鼠, SCID(Mice, SCID);硬皮病, 系统性(Scleroderma, Systemic);皮肤(Skin);Th17细胞(Th17 Cells);转化生长因子β(Transforming Growth Factor beta)
DOI
10.1038/s12276-022-00860-7
PMID
36175484
发布时间
2022-12-15
- 浏览1
Experimental & molecular medicine
1577-1585页
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