Hyperuricemia contributes to glucose intolerance of hepatic inflammatory macrophages and impairs the insulin signaling pathway <i>via</i> IRS2-proteasome degradation.

导出 LinkOut

翻译打印收藏纠错

第一作者： Hairong,Zhao

第一单位： Department of Endocrinology, Xiang'an Hospital of Xiamen University, Xiamen University, Xiamen, China.

作者： Hairong,Zhao ^[1] ; Jiaming,Lu ^[2] ; Furong,He ^[1] ; Mei,Wang ^[1] ; Yunbo,Yan ^[2] ; Binyang,Chen ^[1] ; De,Xie ^[1] ; Chenxi,Xu ^[1] ; Qiang,Wang ^[1] ; Weidong,Liu ^[1] ; Wei,Yu ^[1] ; Yuemei,Xi ^[1] ; Linqian,Yu ^[1] ; Tetsuya,Yamamoto ^[1] ; Hidenori,Koyama ^[3] ; Wei,Wang ^[3] ; Chenggui,Zhang ^[1] ; Jidong,Cheng ^[2]

作者单位： Department of Endocrinology, Xiang'an Hospital of Xiamen University, Xiamen University, Xiamen, China. ^[1] Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical Research and Development (R&D), College of Pharmacy, Dali University, Dali, China. ^[2] Department of Diabetes, Endocrinology and Clinical Immunology, Hyogo College of Medicine, Nishinomiya, Japan. ^[3]

关键词 IRS2-proteasome degradation hyperuricemia inflammatory macrophage insulin resistance of macrophage insulin signaling