Structure-based design and modular synthesis of novel PI4K class II inhibitors bearing a 4-aminoquinazoline scaffold.

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第一作者： Mbilo,Misehe

第一单位： Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo nam. 2, 166 10 Prague 6, Czech Republic; Department of Organic Chemistry, Faculty of Science, Charles University in Prague, Hlavova 2030/8, 128 43 Prague 2, Czech Republic.

作者： Mbilo,Misehe ^[1] ; Martin,Klima ^[2] ; Marika,Matoušová ^[2] ; Dominika,Chalupská ^[2] ; Milan,Dejmek ^[2] ; Michal,Šála ^[2] ; Helena,Mertlíková-Kaiserová ^[2] ; Evzen,Boura ^[2] ; Radim,Nencka ^[3]

作者单位： Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo nam. 2, 166 10 Prague 6, Czech Republic; Department of Organic Chemistry, Faculty of Science, Charles University in Prague, Hlavova 2030/8, 128 43 Prague 2, Czech Republic. ^[1] Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo nam. 2, 166 10 Prague 6, Czech Republic. ^[2] Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo nam. 2, 166 10 Prague 6, Czech Republic. Electronic address: nencka@uochb.cas.cz. ^[3]

关键词 ATP-binding site PI4K2A inhibitor Phosphatidylinositol 4-kinase class II Quinazoline derivative SAR investigation

主题词 1-磷脂酰肌醇4-激酶(1-Phosphatidylinositol 4-Kinase);配体(Ligands);腺苷三磷酸(Adenosine Triphosphate);腺嘌呤(Adenine);构效关系(Structure-Activity Relationship);药物设计(Drug Design)

DOI 10.1016/j.bmcl.2022.129010

PMID 36184029

发布时间 2022-10-27

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