Midkine mediates dysfunction of liver sinusoidal endothelial cells through integrin α4 and α6.

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作者： Li,Wu ^[1] ; Honglin,Chen ^[2] ; Chuankui,Fu ^[2] ; Mulan,Xing ^[2] ; Huihua,Fang ^[3] ; Furong,Yang ^[2] ; Qiaowei,Yang ^[2] ; Yuting,Zhang ^[2] ; Weidong,Li ^[4] ; Zhipeng,Chen ^[4]

作者单位： Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China. Electronic address: wuli@njucm.edu.cn. ^[1] Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China. ^[2] Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China; Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210004, China. ^[3] Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China; Engineering Center of State Ministry of Education for Standardization of Chinese Medicine Processing, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China. ^[4]

关键词 Hepatocellular carcinoma Integrins Liver sinus endothelial cells Midkine Pathological angiogenesis Sinusoidal capillarization