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Dimethandrolone, a Potential Male Contraceptive Pill, is Primarily Metabolized by the Highly Polymorphic UDP-Glucuronosyltransferase 2B17 Enzyme in Human Intestine and Liver.

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第一作者: Sheena,Sharma
第一单位: Department of Pharmaceutical Sciences, Washington State University, Spokane, Washington (S.S., D.A., A.B., D.K.S., B.P.); The Lundquist Institute at Harbor UCLA Medical Center, Torrance, California (M.L., C.W.); Contraceptive Development Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland (M.S.L., D.L.B.); Department of Medicine, University of Washington School of Medicine, Seattle, Washington (J.K.A.); and BioIVT, Halethorpe, Maryland (S.H.).
作者单位: Department of Pharmaceutical Sciences, Washington State University, Spokane, Washington (S.S., D.A., A.B., D.K.S., B.P.); The Lundquist Institute at Harbor UCLA Medical Center, Torrance, California (M.L., C.W.); Contraceptive Development Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland (M.S.L., D.L.B.); Department of Medicine, University of Washington School of Medicine, Seattle, Washington (J.K.A.); and BioIVT, Halethorpe, Maryland (S.H.). [1] Department of Pharmaceutical Sciences, Washington State University, Spokane, Washington (S.S., D.A., A.B., D.K.S., B.P.); The Lundquist Institute at Harbor UCLA Medical Center, Torrance, California (M.L., C.W.); Contraceptive Development Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland (M.S.L., D.L.B.); Department of Medicine, University of Washington School of Medicine, Seattle, Washington (J.K.A.); and BioIVT, Halethorpe, Maryland (S.H.) bhagwat.prasad@wsu.edu. [2]
DOI 10.1124/dmd.122.001041
PMID 36184078
发布时间 2025-02-12
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Drug metabolism and disposition: the biological fate of chemicals

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