Dimethandrolone, a Potential Male Contraceptive Pill, is Primarily Metabolized by the Highly Polymorphic UDP-Glucuronosyltransferase 2B17 Enzyme in Human Intestine and Liver.
第一作者:
Sheena,Sharma
第一单位:
Department of Pharmaceutical Sciences, Washington State University, Spokane, Washington (S.S., D.A., A.B., D.K.S., B.P.); The Lundquist Institute at Harbor UCLA Medical Center, Torrance, California (M.L., C.W.); Contraceptive Development Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland (M.S.L., D.L.B.); Department of Medicine, University of Washington School of Medicine, Seattle, Washington (J.K.A.); and BioIVT, Halethorpe, Maryland (S.H.).
作者:
主题词
人类(Humans);男(雄)性(Male);避孕药, 男用(Contraceptive Agents, Male);葡糖醛酸基转移酶(Glucuronosyltransferase);葡糖醛酸甙类(Glucuronides);微粒体, 肝(Microsomes, Liver);肝(Liver);肠(Intestines);尿苷二磷酸(Uridine Diphosphate)
DOI
10.1124/dmd.122.001041
PMID
36184078
发布时间
2025-02-12
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Drug metabolism and disposition
1493-1500页
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