Genomic landscape of advanced prostate cancer patients with <i>BRCA1</i> versus <i>BRCA2</i> mutations as detected by comprehensive genomic profiling of cell-free DNA.

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第一作者： Umang,Swami

第一单位： Division of Oncology, Department of Internal Medicine, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, United States.

作者： Umang,Swami ^[1] ; Raquel Mae,Zimmerman ^[2] ; Roberto H,Nussenzveig ^[1] ; Edgar Javier,Hernandez ^[2] ; Yeonjung,Jo ^[3] ; Nicolas,Sayegh ^[1] ; Sergiusz,Wesolowski ^[2] ; Lesli A,Kiedrowski ^[4] ; Pedro C,Barata ^[5] ; Gordon Howard,Lemmon ^[2] ; Mehmet A,Bilen ^[6] ; Elisabeth I,Heath ^[7] ; Lakshminarayan,Nandagopal ^[8] ; Hani M,Babiker ^[9] ; Sumanta K,Pal ^[10] ; Michael,Lilly ^[11] ; Benjamin L,Maughan ^[1] ; Benjamin,Haaland ^[3] ; Mark,Yandell ^[2] ; Oliver,Sartor ^[12] ; Neeraj,Agarwal ^[1]

作者单位： Division of Oncology, Department of Internal Medicine, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, United States. ^[1] Human Genetics, University of Utah, Salt Lake City, UT, United States. ^[2] Division of Oncology and Department of Population Health Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, United States. ^[3] Department of Medical Affairs, Guardant Health, Redwood City, CA, United States. ^[4] Deming Department of Medicine, Section of Hematology/Oncology, Tulane University Medical School, New Orleans, LA, United States. ^[5] Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, GA, United States. ^[6] Department of Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, United States. ^[7] Department of Medical Oncology, University of Alabama Medical Center, Birmingham, AL, United States. ^[8] Department of Medical Oncology, Mayo Clinic Florida, Jacksonville, FL, United States. ^[9] Genitourinary Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, United States. ^[10] Division of Hematology and Oncology, Department of Medicine, Medical University of South Carolina, Charleston, SC, United States. ^[11] Tulane Cancer Center, Tulane Medical School, New Orleans, LA, United States. ^[12]

关键词 BRCA1 vs. BRCA2 landscape by cfDNA BRCA1 BRCA2 advanced prostate cancer ctDNA machine learning

DOI 10.3389/fonc.2022.966534

PMID 36185208

发布时间 2024-03-02

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