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Dual-targeted magnetic mesoporous silica nanoparticles reduce brain amyloid-β burden via depolymerization and intestinal metabolism.

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第一作者： Ni,Liu

第一单位： Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, China.;MoE Key Laboratory for Biomedical Photonics, School of Engineering Sciences, Huazhong University of Science and Technology, Wuhan, China.

作者： Ni,Liu ^[1] ; Xiaohan,Liang ^[1] ; Changwen,Yang ^[1] ; Shun,Hu ^[1] ; Qingming,Luo ^[2] ; Haiming,Luo ^[1]

作者单位： Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, China.;MoE Key Laboratory for Biomedical Photonics, School of Engineering Sciences, Huazhong University of Science and Technology, Wuhan, China. ^[1] Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, China.;MoE Key Laboratory for Biomedical Photonics, School of Engineering Sciences, Huazhong University of Science and Technology, Wuhan, China.;School of Biomedical Engineering, Hainan University, Haikou, Hainan 570228, China. ^[2]

关键词 Alzheimer's disease Aβ clearance Aβ42-targeting antibody.amyloid-β (Aβ)magnetic mesoporous silica nanoparticles