OpNAC1 transcription factor regulates the biosynthesis of the anticancer drug camptothecin by targeting loganic acid O-methyltransferase in Ophiorrhiza pumila.

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作者： Xiaolong,Hao ^[1] ; Can,Wang ^[1] ; Wei,Zhou ^[1] ; Qingyan,Ruan ^[1] ; Chenhong,Xie ^[1] ; Yinkai,Yang ^[1] ; Chengyu,Xiao ^[1] ; Yan,Cai ^[1] ; Jingyi,Wang ^[1] ; Yao,Wang ^[1] ; Xuebin,Zhang ^[2] ; Itay,Maoz ^[3] ; Guoyin,Kai ^[1]

作者单位： Laboratory of Medicinal Plant Biotechnology, School of Pharmaceutical Sciences, Academy of Chinese Medical Science, Zhejiang Chinese Medical University, Hangzhou, 310053, China. ^[1] State Key Laboratory of Crop Stress Adaptation and Improvement, Henan Joint International Laboratory for Crop Multi-Omics Research, School of Life Sciences, Henan University, Kaifeng, 475001, China. ^[2] Department of Postharvest Science, ARO, The Volcani Center, HaMaccabim Rd 68, POB 15159, Rishon LeZion, 7528809, Israel. ^[3]

关键词 Ophiorrhiza pumila camptothecin biosynthesis metabolic engineering strategies plant secondary metabolism transcriptional regulation

主题词喜树碱(Camptothecin);抗肿瘤药, 植物(Antineoplastic Agents, Phytogenic);转录因子(Transcription Factors);抗肿瘤药(Antineoplastic Agents);植物(Plants);茜草科(Rubiaceae)

DOI 10.1111/jipb.13377

PMID 36194508

发布时间 2023-02-02

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Journal of integrative plant biology

2023年65卷1期

133-149页

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OpNAC1 transcription factor regulates the biosynthesis of the anticancer drug camptothecin by targeting loganic acid O-methyltransferase in Ophiorrhiza pumila.

Journal of integrative plant biology

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Journal of integrative plant biology

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OpNAC1 transcription factor regulates the biosynthesis of the anticancer drug camptothecin by targeting loganic acid O-methyltransferase in Ophiorrhiza pumila.

Journal of integrative plant biology

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Journal of integrative plant biology

相关期刊

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