Hypoxia is fine-tuned by Hif-1α and regulates mesendoderm differentiation through the Wnt/β-Catenin pathway.

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作者： Xiaopeng,Shen ^[1] ; Meng,Li ^[2] ; Chunguang,Wang ^[3] ; Zhongxian,Liu ^[4] ; Kun,Wu ^[5] ; Ao,Wang ^[6] ; Chao,Bi ^[4] ; Shan,Lu ^[5] ; Hongan,Long ^[6] ; Guoping,Zhu ^[4]

作者单位： Anhui Provincial Key Laboratory of Molecular Enzymology and Mechanism of Major Diseases, College of Life Sciences, Anhui Normal University, Wuhu, 241000, Anhui, China. shenxiaopeng_cn@ahnu.edu.cn. ^[1] Anhui Provincial Key Laboratory of the Conservation and Exploitation of Biological Resources, College of Life Sciences, Anhui Normal University, Wuhu, 241000, Anhui, China. shenxiaopeng_cn@ahnu.edu.cn. ^[2] Key Laboratory of Biomedicine in Gene Diseases and Health of Anhui Higher Education Institutes, College of Life Sciences, Anhui Normal University, Wuhu, 241000, Anhui, China. shenxiaopeng_cn@ahnu.edu.cn. ^[3] Anhui Provincial Key Laboratory of Molecular Enzymology and Mechanism of Major Diseases, College of Life Sciences, Anhui Normal University, Wuhu, 241000, Anhui, China. ^[4] Anhui Provincial Key Laboratory of the Conservation and Exploitation of Biological Resources, College of Life Sciences, Anhui Normal University, Wuhu, 241000, Anhui, China. ^[5] Key Laboratory of Biomedicine in Gene Diseases and Health of Anhui Higher Education Institutes, College of Life Sciences, Anhui Normal University, Wuhu, 241000, Anhui, China. ^[6] Institute of Evolution and Marine Biodiversity, KLMME, Ocean University of China, Qingdao, 266003, Shandong, China. ^[7]

关键词 Akt/Gsk3β axis Ectoderm differentiation Hif-1α Hypoxia Mesendoderm differentiation Mouse embryonic stem cells Wnt/β-Catenin

主题词动物(Animals);小鼠(Mice);原癌基因蛋白质c-akt(Proto-Oncogene Proteins c-akt);β连环素(beta Catenin)

DOI 10.1186/s12915-022-01423-y

PMID 36199093

发布时间 2022-10-19

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