首页> Nature communications> Modeling human telencephalic development and autism-associated SHANK3 deficiency using organoids generated from single neural rosettes.

Modeling human telencephalic development and autism-associated SHANK3 deficiency using organoids generated from single neural rosettes.

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第一作者： Yueqi,Wang

第一单位： Department of Neurobiology, University of Utah, Salt Lake City, UT, USA.;Neuroscience Graduate Program, University of Utah, Salt Lake City, UT, USA.

作者： Yueqi,Wang ^[1] ; Simone,Chiola ^[2] ; Guang,Yang ^[1] ; Chad,Russell ^[3] ; Celeste J,Armstrong ^[2] ; Yuanyuan,Wu ^[2] ; Jay,Spampanato ^[4] ; Paisley,Tarboton ^[3] ; H M Arif,Ullah ^[2] ; Nicolas U,Edgar ^[2] ; Amelia N,Chang ^[5] ; David A,Harmin ^[5] ; Vittoria Dickinson,Bocchi ^[6] ; Elena,Vezzoli ^[6] ; Dario,Besusso ^[6] ; Jun,Cui ^[7] ; Elena,Cattaneo ^[6] ; Jan,Kubanek ^[3] ; Aleksandr,Shcheglovitov ^[8]

作者单位： Department of Neurobiology, University of Utah, Salt Lake City, UT, USA.;Neuroscience Graduate Program, University of Utah, Salt Lake City, UT, USA. ^[1] Department of Neurobiology, University of Utah, Salt Lake City, UT, USA. ^[2] Department of Biomedical Engineering, University of Utah, Salt Lake City, UT, USA. ^[3] Department of Neurosurgery, University of Utah, Salt Lake City, UT, USA. ^[4] Department of Neurobiology, Harvard Medical School, Boston, MA, USA. ^[5] Department of Biosciences, University of Milan, Milan, Italy.;Istituto Nazionale di Genetica Molecolare, Milan, Italy. ^[6] Department of Cell Biology and Neurosciences, Montana State University, Bozeman, MT, USA. ^[7] Department of Neurobiology, University of Utah, Salt Lake City, UT, USA. alexsh@neuro.utah.edu.;Neuroscience Graduate Program, University of Utah, Salt Lake City, UT, USA. alexsh@neuro.utah.edu.;Department of Biomedical Engineering, University of Utah, Salt Lake City, UT, USA. alexsh@neuro.utah.edu. ^[8]

医学主题词孤独性障碍(Autistic Disorder);人类(Humans);神经组织蛋白质类(Nerve Tissue Proteins);类器官(Organoids);端脑(Telencephalon)

DOI 10.1038/s41467-022-33364-z

PMID 36202854

发布时间 2025-06-29

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准确一般字义偏差语意偏离译文作用小提交