首页> The AAPS journal> Preclinical InVivo Data Integrated in a Modeling Network Informs a Refined Clinical Strategy for a CD3 T-Cell Bispecific in Combination with Anti-PD-L1.

Preclinical InVivo Data Integrated in a Modeling Network Informs a Refined Clinical Strategy for a CD3 T-Cell Bispecific in Combination with Anti-PD-L1.

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第一作者： Javier,Sánchez

第一单位： Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070, Basel, Switzerland. javier.sanchez_fernandez@roche.com.;Department of Pharmacy, Uppsala University, Uppsala, Sweden. javier.sanchez_fernandez@roche.com.

作者： Javier,Sánchez ^[1] ; Valeria,Nicolini ^[2] ; Linda,Fahrni ^[2] ; Inja,Waldhauer ^[2] ; Antje-Christine,Walz ^[3] ; Candice,Jamois ^[3] ; Stephen,Fowler ^[3] ; Silke,Simon ^[3] ; Christian,Klein ^[2] ; Pablo,Umaña ^[2] ; Lena E,Friberg ^[4] ; Nicolas,Frances ^[3]

作者单位： Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070, Basel, Switzerland. javier.sanchez_fernandez@roche.com.;Department of Pharmacy, Uppsala University, Uppsala, Sweden. javier.sanchez_fernandez@roche.com. ^[1] Roche Pharma Research and Early Development, Roche Innovation Center Zurich, Schlieren, Switzerland. ^[2] Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070, Basel, Switzerland. ^[3] Department of Pharmacy, Uppsala University, Uppsala, Sweden. ^[4]

关键词 CD3-bispecifics Checkpoint inhibitors Combination PKPD modeling

医学主题词动物(Animals);抗体, 双特异性(Antibodies, Bispecific);细胞系, 肿瘤(Cell Line, Tumor);人类(Humans);黑色素瘤(Melanoma);小鼠(Mice);T淋巴细胞(T-Lymphocytes)

DOI 10.1208/s12248-022-00755-5

PMID 36207642

发布时间 2023-03-31

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准确一般字义偏差语意偏离译文作用小提交