In silico optimization of RNA-protein interactions for CRISPR-Cas13-based antimicrobials.

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作者： Ho-Min,Park ^[1] ; Yunseol,Park ^[2] ; Urta,Berani ^[1] ; Eunkyu,Bang ^[1] ; Joris,Vankerschaver ^[1] ; Arnout,Van Messem ^[1] ; Wesley,De Neve ^[3] ; Hyunjin,Shim ^[4]

作者单位： Center for Biosystems and Biotech Data Science, Ghent University Global Campus, Incheon, South Korea. ^[1] Department of Electronics and Information Systems, Ghent University, Ghent, Belgium. ^[2] Department of Applied Mathematics, Computer Science and Statistics, Ghent University, Ghent, Belgium. ^[3] Department of Mathematics, University of Liège, Liège, Belgium. ^[4] Center for Biosystems and Biotech Data Science, Ghent University Global Campus, Incheon, South Korea. hyunjin.shim@ghent.ac.kr. ^[5]

关键词 CRISPR-based antimicrobials Drug design In silico docking RNA secondary structure RNA tertiary structure RNA–protein interaction Structural biology

主题词抗菌药(Anti-Bacterial Agents);细菌(Bacteria);人类(Humans);RNA, 细菌(RNA, Bacterial);核糖核酸酶类(Ribonucleases)

DOI 10.1186/s13062-022-00339-5

PMID 36207756

发布时间 2022-11-23

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