Investigating the possible mechanisms of pirfenidone to be targeted as a promising anti-inflammatory, anti-fibrotic, anti-oxidant, anti-apoptotic, anti-tumor, and/or anti-SARS-CoV-2.

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作者： Samar A,Antar ^[1] ; Mohamed A,Saleh ^[2] ; Ahmed A,Al-Karmalawy ^[3]

作者单位： Department of Pharmacology and Biochemistry, Faculty of Pharmacy, Horus University, New Damietta 34518, Egypt. Electronic address: santar@horus.edu.eg. ^[1] Department of Clinical Sciences, College of Medicine, University of Sharjah, Sharjah 27272, the United Arab Emirates; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt. ^[2] Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ahram Canadian University, 6th of October City, Giza 12566, Egypt. Electronic address: akarmalawy@acu.edu.eg. ^[3]

关键词 COL1A1 COVID-19 IL-1β PDGF PFD TGF-β1 TNF-α

主题词人类(Humans);转化生长因子β1(Transforming Growth Factor beta1);抗氧化剂(Antioxidants);肿瘤坏死因子α(Tumor Necrosis Factor-alpha);白细胞介素1β(Interleukin-1beta);纤维化(Fibrosis);吡啶酮类(Pyridones);胶原Ⅰ型(Collagen Type I);消炎药(Anti-Inflammatory Agents);血小板源性生长因子(Platelet-Derived Growth Factor);炎症(Inflammation);转化生长因子(Transforming Growth Factors);血管紧张素类(Angiotensins)

DOI 10.1016/j.lfs.2022.121048

PMID 36209833

发布时间 2022-12-17

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Investigating the possible mechanisms of pirfenidone to be targeted as a promising anti-inflammatory, anti-fibrotic, anti-oxidant, anti-apoptotic, anti-tumor, and/or anti-SARS-CoV-2.

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Investigating the possible mechanisms of pirfenidone to be targeted as a promising anti-inflammatory, anti-fibrotic, anti-oxidant, anti-apoptotic, anti-tumor, and/or anti-SARS-CoV-2.

Life sciences

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Life sciences

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