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A multiscale modeling method for therapeutic antibodies in ion exchange chromatography.

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第一作者： David,Saleh

第一单位： Institute of Process Engineering in Life Sciences, Section IV: Biomolecular Separation Engineering, Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany.;Early Stage Bioprocess Development, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany.

作者： David,Saleh ^[1] ; Rudger,Hess ^[1] ; Michelle,Ahlers-Hesse ^[2] ; Federico,Rischawy ^[3] ; Gang,Wang ^[2] ; Jan-Hendrik,Grosch ^[4] ; Thomas,Schwab ^[4] ; Simon,Kluters ^[2] ; Joey,Studts ^[2] ; Jürgen,Hubbuch ^[5]

作者单位： Institute of Process Engineering in Life Sciences, Section IV: Biomolecular Separation Engineering, Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany.;Early Stage Bioprocess Development, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany. ^[1] Late Stage DSP Development, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany. ^[2] Institute of Process Engineering in Life Sciences, Section IV: Biomolecular Separation Engineering, Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany.;Late Stage DSP Development, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany. ^[3] Early Stage Bioprocess Development, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany. ^[4] Institute of Process Engineering in Life Sciences, Section IV: Biomolecular Separation Engineering, Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany. ^[5]

关键词 biopharmaceutical downstream processing ion exchange chromatography mechanistic chromatography modeling multiscale modeling quantitative structure-property relationships

医学主题词色谱法, 离子交换(Chromatography, Ion Exchange);热力学(Thermodynamics);免疫球蛋白G(Immunoglobulin G);抗体, 单克隆(Antibodies, Monoclonal);吸附(Adsorption)

DOI 10.1002/bit.28258

PMID 36226467

发布时间 2023-02-08

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