Bovine cyclic GMP-AMP synthase recognizes exogenous double-stranded DNA and activates the STING-depended interferon β production pathway.

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作者： Haiyue,Dai ^[1] ; Yixiao,Wang ^[2] ; Zhenying,Fan ^[2] ; Yongli,Guo ^[2] ; Jiaqi,Chen ^[2] ; Ye,Meng ^[2] ; Xin,Tong ^[2] ; Mingchun,Gao ^[3] ; Junwei,Wang ^[4]

作者单位： Heilongjiang Provincial Key Laboratory of Zoonosis, Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China; Key Laboratory of Animal Epidemiology and Zoonosis, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China. ^[1] Heilongjiang Provincial Key Laboratory of Zoonosis, Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China. ^[2] Heilongjiang Provincial Key Laboratory of Zoonosis, Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China. Electronic address: gaomingchun@neau.edu.cn. ^[3] Heilongjiang Provincial Key Laboratory of Zoonosis, Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China. Electronic address: jwwang@neau.edu.cn. ^[4]

关键词 Bovine STING Bovine cyclic GMP-AMP synthase DNA recognition Signaling pathway IFN-β production pathway

主题词动物(Animals);DNA(DNA);干扰素β(Interferon-beta)

DOI 10.1016/j.dci.2022.104567

PMID 36228808

发布时间 2023-02-13

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