Traceless cysteine-linchpin enables precision engineering of lysine in native proteins.

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作者： Neelesh C,Reddy ^[1] ; Rajib,Molla ^[1] ; Pralhad Namdev,Joshi ^[1] ; Sajeev,T K ^[2] ; Ipsita,Basu ^[3] ; Jyotsna,Kawadkar ^[2] ; Neetu,Kalra ^[4] ; Ram Kumar,Mishra ^[2] ; Suman,Chakrabarty ^[3] ; Sanjeev,Shukla ^[2] ; Vishal,Rai ^[5]

作者单位： Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Bhopal Bypass Road, Bhauri, Bhopal, 462 066, M.P., India. ^[1] Department of Biological Sciences, Indian Institute of Science Education and Research Bhopal, Bhopal Bypass Road, Bhauri, Bhopal, 462 066, M.P., India. ^[2] Department of Chemical and Biological Sciences, S. N. Bose National Centre for Basic Sciences, Block-JD, Sector-III, Salt Lake, Kolkata, 700 106, W.B., India. ^[3] School of Bioengineering, VIT, Bhopal, India. ^[4] Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Bhopal Bypass Road, Bhauri, Bhopal, 462 066, M.P., India. vrai@iiserb.ac.in. ^[5]

主题词半胱氨酸(Cysteine);免疫轭合物(Immunoconjugates);赖氨酸(Lysine);蛋白质工程(Protein Engineering);蛋白质类(Proteins)

DOI 10.1038/s41467-022-33772-1

PMID 36229616

发布时间 2022-12-22

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