RUNX1/CEBPA Mutation in Acute Myeloid Leukemia Promotes Hypermethylation and Indicates for Demethylation Therapy.

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第一作者： Ekaterina I,Romanova

第一单位： Institute of Bioengineering, Research Center of Biotechnology, Russian Academy of Science, 117312 Moscow, Russia.

作者： Ekaterina I,Romanova ^[1] ; Anatoliy V,Zubritskiy ^[1] ; Anna V,Lioznova ^[1] ; Adewale J,Ogunleye ^[2] ; Vasily A,Golotin ^[3] ; Anna A,Guts ^[4] ; Andreas,Lennartsson ^[5] ; Oleg N,Demidov ^[6] ; Yulia A,Medvedeva ^[7]

作者单位： Institute of Bioengineering, Research Center of Biotechnology, Russian Academy of Science, 117312 Moscow, Russia. ^[1] Department of Biomedical Physics. Moscow Institute of Physics and Technology, 141701 Dolgoprudny, Russia. ^[2] Institute of Cytology, RAS, Laboratory of Molecular Medicine, 194064 St. Petersburg, Russia. ^[3] State Research Institute of Lake and River Fisheries, 199053 St. Petersburg, Russia. ^[4] INSERM UMR1231, University of Burgundy Franche-Comté, 21078 Dijon, France. ^[5] Institute of Pharmacy, Sechenov University, 119435 Moscow, Russia. ^[6] Department of Biosciences and Nutrition, Karolinska Instituten, 141 83 Huddinge, Sweden. ^[7] Sirius University of Science and Technology, 354340 Sochi, Russia. ^[8]

关键词 AML BIK CEBPA DNA methylation RUNX1 TET2 epigenetics

主题词 CCAAT增强子结合蛋白类(CCAAT-Enhancer-Binding Proteins);核心结合因子α2亚基(Core Binding Factor Alpha 2 Subunit);DNA(DNA);DNA甲基化(DNA Methylation);人类(Humans);白血病, 髓样, 急性(Leukemia, Myeloid, Acute);突变(Mutation)

DOI 10.3390/ijms231911413

PMID 36232714

发布时间 2022-10-19

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