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Synthesis of Novel Lipophilic Polyamines via Ugi Reaction and Evaluation of Their Anticancer Activity.

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第一作者： Artemiy,Nichugovskiy

第一单位： Lomonosov Institute of Fine Chemical Technologies, MIREA-Russian Technological University, 86 Vernadsky Ave., 119571 Moscow, Russia.

作者： Artemiy,Nichugovskiy ^[1] ; Varvara,Maksimova ^[2] ; Ekaterina,Trapeznikova ^[3] ; Elizaveta,Eshtukova-Shcheglova ^[1] ; Igor,Ivanov ^[1] ; Marianna,Yakubovskaya ^[2] ; Kirill,Kirsanov ^[4] ; Dmitry,Cheshkov ^[5] ; Gian Cesare,Tron ^[6] ; Mikhail,Maslov ^[1]

作者单位： Lomonosov Institute of Fine Chemical Technologies, MIREA-Russian Technological University, 86 Vernadsky Ave., 119571 Moscow, Russia. ^[1] N.N. Blokhin National Medical Research Center of Oncology, 23 Kashirskoe Sh., 115478 Moscow, Russia. ^[2] I.M. Sechenov First Moscow State Medical University, 8-2 Trubetskaya Str., 119991 Moscow, Russia. ^[3] N.N. Blokhin National Medical Research Center of Oncology, 23 Kashirskoe Sh., 115478 Moscow, Russia.;Institute of Medicine, Peoples' Friendship University of Russia, 6 Miklukho-Maklaya Str., 117198 Moscow, Russia. ^[4] State Scientific Research Institute of Chemistry and Technology of Organoelement Compounds, 38 Shosse Entuziastov, 105118 Moscow, Russia. ^[5] Dipartimento di Scienza del Farmaco, Università del Piemonte Orientale, 2 Largo Donegani, 28100 Novara, Italy. ^[6]

关键词 anticancer activity lipophilic polyamines multicomponent Ugi reaction polyamines

医学主题词酰胺类(Amides);抗肿瘤药(Antineoplastic Agents);甘油二酯类(Diglycerides);人类(Humans);肿瘤(Neoplasms);哌嗪类(Piperazines);聚胺类(Polyamines)

DOI 10.3390/molecules27196218

PMID 36234753

发布时间 2022-10-19

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