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A comprehensive transcriptomic comparison of hepatocyte model systems improves selection of models for experimental use.

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第一作者： Arif Ibrahim,Ardisasmita

第一单位： Division of Pediatric Gastroenterology, Wilhelmina Children's Hospital, University Medical Center Utrecht, 3584 EA, Utrecht, the Netherlands.;Department of Metabolic Diseases, Wilhelmina Children's Hospital, University Medical Center Utrecht, 3584 EA, Utrecht, the Netherlands.;Regenerative Medicine Center Utrecht, 3584 CT, Utrecht, the Netherlands.

作者： Arif Ibrahim,Ardisasmita ^[1] ; Imre F,Schene ^[1] ; Indi P,Joore ^[1] ; Gautam,Kok ^[1] ; Delilah,Hendriks ^[2] ; Benedetta,Artegiani ^[3] ; Michal,Mokry ^[4] ; Edward E S,Nieuwenhuis ^[5] ; Sabine A,Fuchs ^[6]

作者单位： Division of Pediatric Gastroenterology, Wilhelmina Children's Hospital, University Medical Center Utrecht, 3584 EA, Utrecht, the Netherlands.;Department of Metabolic Diseases, Wilhelmina Children's Hospital, University Medical Center Utrecht, 3584 EA, Utrecht, the Netherlands.;Regenerative Medicine Center Utrecht, 3584 CT, Utrecht, the Netherlands. ^[1] Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences, Utrecht, the Netherlands. ^[2] Princess Maxima Center, 3584 CS, Utrecht, the Netherlands. ^[3] Division of Pediatric Gastroenterology, Wilhelmina Children's Hospital, University Medical Center Utrecht, 3584 EA, Utrecht, the Netherlands.;Laboratory of Clinical Chemistry and Haematology, University Medical Center, Utrecht, the Netherlands.;Department of Cardiology, University Medical Center, Utrecht, the Netherlands. ^[4] Division of Pediatric Gastroenterology, Wilhelmina Children's Hospital, University Medical Center Utrecht, 3584 EA, Utrecht, the Netherlands.;Department of Sciences, University College Roosevelt, 4331 CB, Middelburg, the Netherlands. ^[5] Department of Metabolic Diseases, Wilhelmina Children's Hospital, University Medical Center Utrecht, 3584 EA, Utrecht, the Netherlands. S.Fuchs@umcutrecht.nl.;Regenerative Medicine Center Utrecht, 3584 CT, Utrecht, the Netherlands. S.Fuchs@umcutrecht.nl. ^[6]

医学主题词细胞分化(Cell Differentiation);肝细胞(Hepatocytes);人类(Humans);诱导多能干细胞(Induced Pluripotent Stem Cells);多潜能干细胞(Pluripotent Stem Cells)

DOI 10.1038/s42003-022-04046-9

PMID 36241695

发布时间 2022-12-20

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A comprehensive transcriptomic comparison of hepatocyte model systems improves selection of models for experimental use.

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A comprehensive transcriptomic comparison of hepatocyte model systems improves selection of models for experimental use.

Communications biology

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