Genomic Stratification of Clozapine Prescription Patterns Using Schizophrenia Polygenic Scores.

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第一作者： Djenifer B,Kappel

第一单位： MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, United Kingdom.

作者： Djenifer B,Kappel ^[1] ; Sophie E,Legge ^[1] ; Leon,Hubbard ^[1] ; Isabella R,Willcocks ^[1] ; Kevin S,O'Connell ^[2] ; Robert L,Smith ^[3] ; Espen,Molden ^[4] ; Ole A,Andreassen ^[2] ; Adrian,King ^[5] ; John,Jansen ^[6] ; Marinka,Helthuis ^[6] ; Michael J,Owen ^[1] ; Michael C,O'Donovan ^[1] ; James T R,Walters ^[1] ; Antonio F,Pardiñas ^[7]

作者单位： MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, United Kingdom. ^[1] Norwegian Centre for Mental Disorders Research, Division of Mental Health and Addiction, University of Oslo and Oslo University Hospital, Oslo, Norway. ^[2] Norwegian Centre for Mental Disorders Research, Division of Mental Health and Addiction, University of Oslo and Oslo University Hospital, Oslo, Norway; Center for Psychopharmacology, Diakonhjemmet Hospital, Oslo, Norway. ^[3] Section for Pharmacology and Pharmaceutical Biosciences, Department of Pharmacy, University of Oslo, Oslo, Norway; Center for Psychopharmacology, Diakonhjemmet Hospital, Oslo, Norway. ^[4] Magna Laboratories Ltd., Ross-on-Wye, United Kingdom. ^[5] Leyden Delta BV, Nijmegen, the Netherlands. ^[6] MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, United Kingdom. Electronic address: PardinasA@cardiff.ac.uk. ^[7]

关键词 Clozapine Genomics Pharmacogenomics Polygenic risk scores Precision medicine Schizophrenia

主题词人类(Humans);氯氮平(Clozapine);精神分裂症(Schizophrenia);抗精神病药(Antipsychotic Agents);处方(Prescriptions);基因组学(Genomics)

DOI 10.1016/j.biopsych.2022.07.014

PMID 36244804

发布时间 2024-10-23

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