BNT162b2-induced neutralizing and non-neutralizing antibody functions against SARS-CoV-2 diminish with age.

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作者： Timothy A,Bates ^[1] ; Pei,Lu ^[2] ; Ye Jin,Kang ^[2] ; Devin,Schoen ^[3] ; Micah,Thornton ^[4] ; Savannah K,McBride ^[1] ; Chanhee,Park ^[4] ; Daehwan,Kim ^[4] ; William B,Messer ^[1] ; Marcel E,Curlin ^[5] ; Fikadu G,Tafesse ^[6] ; Lenette L,Lu ^[7]

作者单位： Department of Molecular Microbiology and Immunology, Oregon Health and Sciences University, Portland, OR 97239, USA. ^[1] Division of Infectious Diseases and Geographic Medicine, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX 75390, USA. ^[2] Department of Occupational Health, Oregon Health and Sciences University, Portland, OR 97239, USA. ^[3] Lyda Hill Department of Bioinformatics, UT Southwestern Medical Center, Dallas, TX 75390, USA. ^[4] Department of Occupational Health, Oregon Health and Sciences University, Portland, OR 97239, USA. Electronic address: curlin@ohsu.edu. ^[5] Department of Molecular Microbiology and Immunology, Oregon Health and Sciences University, Portland, OR 97239, USA. Electronic address: tafesse@ohsu.edu. ^[6] Division of Infectious Diseases and Geographic Medicine, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX 75390, USA; Department of Immunology, UT Southwestern Medical Center, Dallas, TX 75390, USA; Parkland Health & Hospital System, Dallas, TX 75235, USA. Electronic address: lenette.lu@utsouthwestern.edu. ^[7]

关键词 COVID-19 CP: Immunology Fc effector functions Fc receptor Omicron SARS-CoV-2 antibody glycosylation neutralization vaccine

主题词人类(Humans);老年人(Aged);抗体, 病毒(Antibodies, Viral);病毒疫苗(Viral Vaccines);受体, Fc(Receptors, Fc);抗体, 中和(Antibodies, Neutralizing)

DOI 10.1016/j.celrep.2022.111544

PMID 36252569

发布时间 2024-09-23

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