Targeting inhibition of microtubule affinity regulating kinase 4 by Harmaline: Strategy to combat Alzheimer's disease.

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第一作者： Mohd,Adnan

第一单位： Department of Biology, College of Science, University of Ha'il, Ha'il, P.O. Box 2440, Saudi Arabia.

作者： Mohd,Adnan ^[1] ; Saleha,Anwar ^[2] ; Debarati,DasGupta ^[3] ; Mitesh,Patel ^[4] ; Abdelbaset Mohamed,Elasbali ^[5] ; Hassan H,Alhassan ^[6] ; Alaa,Shafie ^[7] ; Arif Jamal,Siddiqui ^[1] ; Fevzi,Bardakci ^[1] ; Mejdi,Snoussi ^[1] ; Md Imtaiyaz,Hassan ^[8]

作者单位： Department of Biology, College of Science, University of Ha'il, Ha'il, P.O. Box 2440, Saudi Arabia. ^[1] Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India. ^[2] College of Pharmacy, University of Michigan, 428 Church Street, Ann Arbor, MI 48109, USA. ^[3] Department of Biotechnology, Parul Institute of Applied Sciences and Centre of Research for Development, Parul University, Vadodara 391760, India. ^[4] Department of Clinical Laboratory Science, College of Applied Medical Sciences, Qurayyat, Jouf University, Saudi Arabia. ^[5] Department of Clinical Laboratory Science, College of Applied Medical Sciences, Qurayyat, Jouf University, Saudi Arabia; Department of Clinical Laboratory Science, College of Applied Medical Sciences, Sakaka, Jouf University, Saudi Arabia. ^[6] Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, Taif, Saudi Arabia. ^[7] Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India. Electronic address: mihassan@jmi.ac.in. ^[8]

关键词 Alzheimer's disease Drug discovery Harmaline Kinase inhibitors MD simulations Microtubule affinity regulating kinase 4 Molecular docking

主题词人类(Humans);哈马灵(Harmaline);蛋白质结合(Protein Binding);阿尔茨海默病(Alzheimer Disease);微管(Microtubules);抗肿瘤药(Antineoplastic Agents)

DOI 10.1016/j.ijbiomac.2022.10.115

PMID 36257368

发布时间 2022-12-22

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