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首页> Journal of medicinal chemistry> Identification of 1,4-Benzodiazepine-2,5-dione Derivatives as Potential Protein Synthesis Inhibitors with Highly Potent Anticancer Activity.

Identification of 1,4-Benzodiazepine-2,5-dione Derivatives as Potential Protein Synthesis Inhibitors with Highly Potent Anticancer Activity.

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第一作者： Wenjun,Yu

第一单位： School of Pharmaceutical Sciences, Tsinghua University, Haidian Dist, Beijing 100084, P. R. China.

作者： Wenjun,Yu ^[1] ; Xilei,Xie ^[2] ; Yao,Ma ^[3] ; Shiping,Fang ^[2] ; Yi,Dong ^[1] ; Gang,Liu ^[2]

作者单位： School of Pharmaceutical Sciences, Tsinghua University, Haidian Dist, Beijing 100084, P. R. China. ^[1] Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, 2A Nanwei Rd, Xicheng Dist, Beijing 100050, P. R. China. ^[2] College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan 250014, P. R. China. ^[3] Key laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education; Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai 264005, P. R. China. ^[4]

主题词人类(Humans);小鼠(Mice);动物(Animals);药物筛选试验, 抗肿瘤(Drug Screening Assays, Antitumor);蛋白质合成抑制药(Protein Synthesis Inhibitors);细胞增殖(Cell Proliferation);抗肿瘤药(Antineoplastic Agents);癌, 非小细胞肺(Carcinoma, Non-Small-Cell Lung);肺肿瘤(Lung Neoplasms);细胞系, 肿瘤(Cell Line, Tumor);细胞凋亡(Apoptosis);构效关系(Structure-Activity Relationship);剂量效应关系, 药物(Dose-Response Relationship, Drug);分子结构(Molecular Structure)

DOI 10.1021/acs.jmedchem.2c01431

PMID 36260776

发布时间 2022-12-04

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Journal of medicinal chemistry

Journal of medicinal chemistry

2022年65卷21期

14891-14915页

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