Mitochondrial aggregation caused by cytochalasin B compromises the efficiency and safety of three-parent embryo.

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作者： Ying,Li ^[1] ; Sanbao,Shi ^[2] ; Jin,Yuan ^[3] ; Xi,Xiao ^[4] ; Dongmei,Ji ^[1] ; Jianxin,Pan ^[3] ; Zhunyuan,Min ^[2] ; Hao,Wang ^[2] ; Hongying,Sha ^[2] ; Yazhong,Ji ^[2]

作者单位： Reproductive Medicine Center, Tongji Hospital Affiliated to Tongji University, Shanghai, China. ^[1] State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai, China. ^[2] Department of Obstetrics and Gynecology, Center for Reproductive Medicine, The First Hospital Affiliated for Anhui Medical University, Hefei, China. ^[3] The International Peace Maternal and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. ^[4]

关键词 cytochalasin B germ cells mitochondrial replacement mtDNA heteroplasmy oocyte

主题词人类(Humans);小鼠(Mice);动物(Animals);细胞松弛素B(Cytochalasin B);胚胎, 哺乳动物(Embryo, Mammalian);卵母细胞(Oocytes);DNA, 线粒体(DNA, Mitochondrial)

DOI 10.1093/molehr/gaac036

PMID 36264122

发布时间 2022-11-29

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