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Spatial heterogeneity and organization of tumor mutation burden with immune infiltrates within tumors based on whole slide images correlated with patient survival in bladder cancer.

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第一作者： Hongming,Xu

第一单位： School of Biomedical Engineering, Faculty of Electronic Information and Electrical Engineering, Dalian University of Technology, Dalian 116024, China.;Liaoning Key Laboratory of Integrated Circuit and Biomedical Electronic System, Dalian University of Technology, Dalian 116024, China.

作者： Hongming,Xu ^[1] ; Jean René,Clemenceau ^[2] ; Sunho,Park ^[2] ; Jinhwan,Choi ^[2] ; Sung Hak,Lee ^[3] ; Tae Hyun,Hwang ^[2]

作者单位： School of Biomedical Engineering, Faculty of Electronic Information and Electrical Engineering, Dalian University of Technology, Dalian 116024, China.;Liaoning Key Laboratory of Integrated Circuit and Biomedical Electronic System, Dalian University of Technology, Dalian 116024, China. ^[1] Department of Artificial Intelligence and Informatics, Mayo Clinic, Jacksonville, FL 32224, USA. ^[2] Department of Hospital Pathology, Seoul St.Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, South Korea. ^[3]

关键词 BLCA, Urothelial Bladder Carcinoma Bladder cancer Computational pathology Spatial Heterogeneity Survival prognosis TCGA, The Cancer Genome Atlas Project TIL, Tumor-Infiltrating Lymphocyte TMB, Tumor Mutation Burden Tumor Immune Microenvironment Tumor mutation burden prediction WSI, Whole Slide Image

DOI 10.1016/j.jpi.2022.100105

PMID 36268064

发布时间 2024-05-20

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